S3944

SEW2871

≥98% (HPLC), solid

• 別名: 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole
• 実験式（ヒル表記法）: C₂₀H₁₀F₆N₂OS
• CAS番号: 256414-75-2
• 分子量: 440.36
• MDL番号: MFCD00096600
• UNSPSCコード: 12352211
• PubChem Substance ID: 24724607
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: protect from light
• 色: white
• mp: 94.5-95.3 °C
• 溶解性: DMSO: ≥10 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
• InChI: 1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
• InChI Key: OYMNPJXKQVTQTR-UHFFFAOYSA-N
• 遺伝子情報: human ... S1PR1(1901) , S1PR2(9294) , S1PR3(1903) , S1PR4(8698) , S1PR5(53637)

詳細

アプリケーション

SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice.[1]

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.[2]

生物化学的／生理学的作用

Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist.

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation.[3] SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration.[4] By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.[5]

特徴および利点

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

包装

Light sensitive.

安全性情報

• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges