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リコンビナント
expressed in E. coli
品質水準
アッセイ
≥90% (SDS-PAGE)
フォーム
lyophilized powder (one vial contains one mg protein)
比活性
≥100 units/mg protein
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... NQO2(4835)
アプリケーション
Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
生物化学的／生理学的作用
NAD(P)Hではなく、ジヒドロニコチンアミドリボシド(NRH)を補助基質として用いるユニ-クなヒトオキシドレダクタ-ゼ。抗癌プロドラッグを活性化します。 推定的メラトニン受容体
Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.[1]
単位の定義
One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.
物理的形状
contains 10% PBS buffer salts
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
Q0380-PH:
Q0380PROC:
Q0380-1MG-PW:
Q0380-1MG:
Q0380-BULK:
Q0380-VAR:
Paraquat Research. Do Recent Advances In Limiting Its Toxicity Make Its Use Safer?
Baltazar, T., et al.
British Journal of Pharmacology (2012)
Effect of Afobazole on Activity of Quinone Reductase 2
Kadnikov IA, et al.
Pharmaceutical Chemistry Journal, 47(10), 514-516 (2014)
Karen A Nolan et al.
Molecular cancer therapeutics, 11(1), 194-203 (2011-11-18)
The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one
K A Nolan et al.
Bioorganic & medicinal chemistry letters, 20(9), 2832-2836 (2010-04-02)
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most
Qiuying Cheng et al.
Biochemical pharmacology, 83(1), 139-148 (2011-10-18)
Carbonyl reductase activity catalyzes the two electron reduction of several endogenous and exogenous carbonyl substrates. Recent data indicate that the expression of human carbonyl reductase 3 (CBR3) is regulated by the master redox switch Nrf2. Nrf2 binds to conserved antioxidant
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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