SRP6539

NQO1 ヒト

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• 別名: Azoreductase, DT-Diaphorase (DTD), Dioxin-inducible 1, Disphorase-4 (DIA4), Menadione Reductase, NAD(P)H Dehydrogenase (Quinine) 1 (NQO1), NAD(P)H Quinone Oxireductase, Phylloquinone Reductase, Quinone Oxidoreductase 1, Quinone Reductase 1 (QR1)
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥90% (SDS-PAGE)
• フォーム: liquid
• 分子量: ~30 kDa (Human NQO1 aa 1-274 is fused at the C-terminus to a His-tag.)
• 包装: pkg of 10 and 50 μg
• 不純物: <0.1 EU/μg endotoxin (LAL test)
• UniProtアクセッション番号: P15559
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... NQO1(1728)

詳細

詳細

Research area: Cell signaling. NQO1 (NAD(P)H quinone dehydrogenase 1) is an obligate two-electron reductase. It is a cytoplasmic, homodimeric protein, with one FAD molecule per monomer. This gene is localized to human chromosome 16q23.[1][2] It shows a wide range of tissue expression.[3]

生物化学的／生理学的作用

NQO1 (NAD(P)H quinone dehydrogenase 1) uses NADH or NADPH as a reducing cofactor, and is characterized by its inhibition by dicoumarol. It is thought to confer protection against natural and exogenous quinones.[1] It is involved in the conversion of benzene derived quinones to less toxic hydroquinones, and participates in benzene-associated hematotoxicity. It is involved in the reduction and eventual activation of few chemotherapeutic drugs and of environmental carcinogens, such as heterocyclic amines, nitroaromatic compounds, and possibly cigarette smoke particulate.[2] C609T null variant of this gene is linked with breast cancer susceptibility in north Indian patients.[4] NQO1 is up-regulated in serous ovarian carcinoma, and this expression is linked with poor prognosis; hence, this gene has potential as biomarker for the same.[5]

物理的形状

0.2 μm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H319
• 注意書き: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable