おすすめの製品
由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
7E3-1B8, monoclonal
フォーム
buffered aqueous solution
分子量
antigen 95 kDa
化学種の反応性
rat
テクニック
immunofluorescence: 1:500
immunoprecipitation (IP): suitable
western blot: 1:2,000
アイソタイプ
IgG2a
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
rat ... Dlg4(29495)
詳細
DLG4 (discs large MAGUK scaffold protein 4) gene codes for the postsynaptic density-95 (PSD95) protein. Postsynaptic density 95 (PSD-95), a synaptic scaffolding protein is also a membrane-associated guanylate kinase (MAGUK) family protein. It has three PDZ domains on the N terminus followed by a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. This gene is located on human chromosome 17p13.1.
特異性
組み換え型および天然型PSD95のどちらとも反応します。ラット海馬細胞の免疫蛍光法において、シナプス部位のNMDA受容体の染色と一致し、提唱されている受容体クラスタリングにおける役割と一致する染色パタ-ンが認められます。冷メタノ-ルでの固定を推奨します。
免疫原
組み換え型ラットPSD95 (シナプス後膜肥厚95 kDa)。
アプリケーション
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
生物化学的／生理学的作用
Postsynaptic density 95 (PSD-95) plays a major role in bidirectional synaptic plasticity, an important process, essential for learning and memory. It exhibits increased dynamics upon induction of plasticity.
物理的形状
PBS溶液 (0.05%アジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P246-100UL-PW:
P246-BULK:
P246-VAR:
P246-100UL:
最新バージョンのいずれかを選択してください：
試験成績書（COA）
Lot/Batch Number
この製品を見ている人はこちらもチェック
Lindsey I Sinclair et al.
Neuropathology and applied neurobiology, 41(4), 533-543 (2015-01-07)
Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied
Nora Overlack et al.
Vision research, 48(3), 400-412 (2007-10-10)
The human Usher syndrome (USH) is the most common form of combined deaf-blindness. Usher type I (USH1), the most severe form, is characterized by profound congenital deafness, constant vestibular dysfunction and prepubertal-onset of retinitis pigmentosa. Five corresponding genes of the
Chongbo Zhong et al.
eNeuro, 4(1) (2017-03-10)
Altered neuregulin 1 (Nrg1)/ErbB signaling and glutamatergic hypofunction have been implicated in the pathophysiology of schizophrenia. Here, we employed gene chimeric ventral hippocampus (vHipp)-nucleus accumbens (nAcc) coculture from mouse, electrophysiology, immunocytochemistry, FM1-43 vesicle fusion, and electron microscopy techniques to examine
Lindsey I Sinclair et al.
Journal of Alzheimer's disease : JAD, 59(3), 1123-1137 (2017-07-22)
Possession of APOEɛ4 is a strong risk factor for late-onset Alzheimer's disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer's disease. We hypothesized that ɛ4 allele possession in non-demented adults aged
Malwina Lisek et al.
Frontiers in cellular neuroscience, 11, 181-181 (2017-07-14)
Ketamine causes psychotic episodes and is often used as pharmacological model of psychotic-like behavior in animals. There is increasing evidence that molecular mechanism of its action is more complicated than just N-methyl-D-aspartic acid (NMDA) receptor antagonism and involves interaction with
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