P2200

プロテイン C ヒト血漿由来

Activated, lyophilized powder, ≥90% (SDS-PAGE)

• 別名: 活性化プロテインC
• CAS番号: 42617-41-4
• Enzyme Commission number: 3.4.21.69 (BRENDA, IUBMB)
• MDL番号: MFCD00165567
• UNSPSCコード: 12352202
• NACRES: NA.61

特性

• 由来生物: human plasma
• 品質水準: 200
• アッセイ: ≥90% (SDS-PAGE)
• フォーム: lyophilized powder
• 分子量: heavy chain 41 kDa; light chain 21 kDa
• テクニック: inhibition assay: suitable
• 溶解性: H₂O: 1 mg/mL
• UniProtアクセッション番号: P04070
• 保管温度: −20°C
• 遺伝子情報: human ... PROC(5624)

詳細

詳細

Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14.[1] Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects.[2] Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.[3]

アプリケーション

Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay.[2] It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.[4]

生物化学的／生理学的作用

In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells. [5]

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.

物理的形状

0.1 M NaClを含有するpH 7.4の20 mM Tris-HCl溶液の凍結乾燥品

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable