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Merck

P2191

Sigma-Aldrich

ポリ(D,L-ラクチド--グリコリド)

lactide:glycolide (50:50), mol wt 30,000-60,000

別名:

LACTEL® B6010-2, PLGA

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1 G
¥41,200
5 G
¥70,500

¥41,200

単価¥51,500割引20%

在庫あり詳細


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サイズを選択してください

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1 G
¥41,200
5 G
¥70,500

About This Item

化学式:
[C3H4O2]x[C2H2O2]y
MDL番号:
UNSPSCコード:
12352211
PubChem Substance ID:
NACRES:
NA.25

¥41,200

単価¥51,500割引20%

在庫あり詳細


バルクの問い合わせ

原料比

lactide:glycolide (50:50)

品質水準

分子量

30,000-60,000

保管温度

−20°C

SMILES記法

OCC(O)=O.CC(O)C(O)=O

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詳細

ポリ(D,L-ラクチド-コ-グリコリド)は、薬物送達に使用される生分解性かつ生体適合性ポリマーです。[1]関節リウマチ、潰瘍性大腸炎、クローン病、炎症性肺疾患および炎症性眼疾患の治療に使用されます。ポリ(D,L-ラクチド-コ-グリコリド)は、潜在的ながん治療標的として機能します。[2]

アプリケーション

ポリ(D,L-ラクチド-コ-グリコリド)は、皮膚外傷に関係する濃度でゲル中に増加した乳酸モノマーのレベルを上昇および維持するために使用されています。[3]

特徴および利点

生物活性剤の制御された放出、縫合や生体吸収性の移植可能なデバイス。

物理的形状

生体適合性、生物分解性ポリマ-。

法的情報

Lactel is a registered trademark of Evonik Corp

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

P2191-100MG:
P2191-VAR:
P2191-1G:
P2191-BULK:
P2191-5G:
P2191-500MG:


最新バージョンのいずれかを選択してください:

試験成績書(COA)

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
Hunt TK, et al.
Antioxidants & Redox Signaling, 9(8), 1115-1124 (2007)
Characterization of biodegradable poly (D, L-lactide-co-glycolide) polymers and microspheres
Hausberger AG and DeLuca PP
Journal of Pharmaceutical and Biomedical Analysis, 13(6), 747-760 (1995)
PLGA-based nanoparticles: an overview of biomedical applications
Danhier F, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 161(2), 505-522 (2012)
Ahmed A Abd-Rabou et al.
Biological trace element research, 193(2), 377-389 (2019-05-09)
Colon cancer in men and breast cancer in women are regarded as major health burdens, accounting for majority of cancer diagnoses globally. Doxorubicin (DOX) resistance in breast and colon cancers represents the main reason of unsuccessful therapy. The rationale of
Habibun Nabi et al.
Parasitology research, 116(1), 359-370 (2016-10-28)
Toxoplasmosis is one of the most common zoonotic protozoal diseases. Recent advances in biotechnology have produced recombinant protein, which are immunogenic, and progress in nano-pharmaceutics has generated encapsulated protein in nanospheres, which are suitable for vaccine delivery. DNA was extracted

質問

1–7/7 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Please give me the detailed solubility profiling of this product with the solvent: Acetonitrile and Methanol

    1 回答
    1. This product is not tested for solubility. However, other sources report that this material is soluble in acetone at 5 wt%. Other solvents listed are dichloromethane, tetrahydrofuran, ethyl acetate, and chloroform. No rate is provided. This information has not been validated.

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  4. What is the glass transition temperature of Product P2191, Poly(D,L-lactide-co-glycolide)?

    1 回答
    1. The glass transition is 45-50°C; the melting point is amorphous.

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  5. What is the viscosity of Product P2191, Poly(D,L-lactide-co-glycolide)?

    1 回答
    1. The viscosity of this product is lot-specific and can be found in the Certificate of Analysis.

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  6. What is the Department of Transportation shipping information for this product?

    1 回答
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  7. Product P2191, Poly(D,L-lactide-co-glycolide), is a compound that is useful as a time-release agent in delivery systems such as herbicides, pesticides, and drugs.  What is the rate of degradation?

    1 回答
    1. The higher the lactic acid to glycolic acid ratio, the slower is the degradation rate of the polymer.  Molecular weight of the polymer is a contributing factor to the degradation; the lower the molecular weight, the faster the degradation rate of the polymer.

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