The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.
免疫原
NSO細胞で発現させたリコンビナントマウスオステオポンチンの精製物。
生物化学的/生理学的作用
Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.
物理的形状
凍結乾燥品 (PBS溶液, 5%トレハロ-ス含有, 0.2μmフィルタ-滅菌済み)。
アナリシスノート
293細胞を使用したリコンビナントマウスオステオポンチンの生物活性を中和します。
免責事項
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10778-10800 (2020-07-04)
Chronic graft-vs-host disease (cGVHD) is a multifactorial inflammatory disease that affects patients undergoing hematopoietic stem cell transplantation. Multiple organs, including the lacrimal glands (LGs), are negatively affected by cGVHD and lose function due to the resultant fibrosis. An abnormal immune