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Merck

L9879

Sigma-Aldrich

リコピン

≥90%, from tomato

別名:

ψ,ψ-カロテン, 2,6,10,14,19,23,27,31-オクタメチル-ドトリアコンタ-2,6,8,10,12,14,16,18,20,22,24,26,30-トリデカエン

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About This Item

実験式(ヒル表記法):
C40H56
CAS番号:
分子量:
536.87
EC Number:
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:

由来生物

tomato

アッセイ

≥90%

フォーム

powder

輸送温度

dry ice

保管温度

−70°C

SMILES記法

C\C(C)=C\CC\C(C)=C\C=C\C(C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C=C(/C)CC\C=C(\C)C

InChI

1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+

InChI Key

OAIJSZIZWZSQBC-GYZMGTAESA-N

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詳細

リコペンは天然に存在する赤色色素であり、カロテノイド族に属します。トマト、スイカおよびパパイヤ中に見出されます。リコペンは抗酸化作用を有します。[1]

アプリケーション

リコペンは下記に使用されます。
  • 高速液体クロマトグラフィー(HPLC)による、肝臓、腎臓および胚組織中の濃度の同定[2]
  • 前立腺がん細胞株におけるウロキナーゼ・プラスミノーゲン活性化因子受容体(uPAR)活性化[3]
  • ラマン化学イメージングにおける内部分布の検出および可視化[4]

生物化学的/生理学的作用

トマトに含まれる抗酸化性の微量栄養素で、がんや心血管疾患のリスクを低減します。Connexin 43のアップレギュレ-ションを介して細胞間のギャップ結合における情報伝達を促進し、培養がん細胞の増殖を抑制します。コレステロ-ル合成を阻害し、低密度リポタンパク質の分解を促進します。

包装

密封アンプル入り。

関連製品

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

L9879-VAR:
L9879-10MG-PW:
L9879PROC:
L9879-10MG:
L9879-1MG-PW:
L9879-1MG:
L9879-5MG:
L9879-PH:
L9879-BULK:


最新バージョンのいずれかを選択してください:

試験成績書(COA)

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

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Slide 1 of 6

1 of 6

Chun-Ming Shih et al.
Polymers, 12(7) (2020-07-15)
Lycopene is the most abundant carotenoid in tomatoes, which has been identified to have the properties of anti-inflammation in addition to the capability to inhibit the expression of adhesion molecules. Intercellular adhesion molecules play a critical role in the pathogenesis
Harris H Wang et al.
Nature, 460(7257), 894-898 (2009-07-28)
The breadth of genomic diversity found among organisms in nature allows populations to adapt to diverse environments. However, genomic diversity is difficult to generate in the laboratory and new phenotypes do not easily arise on practical timescales. Although in vitro
Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line: a brief communication
Forbes K, et al.
Exp. Biol. Med, 228(8), 967-971 (2003)
Arnab Chattopadhyay et al.
Journal of lipid research, 54(4), 995-1010 (2013-02-05)
Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested, lyophilized, ground into powder, added to Western diet (WD) at 2.2% by weight, and fed
Wilhelm Stahl et al.
Skin pharmacology and applied skin physiology, 15(5), 291-296 (2002-09-20)
Upon exposure to UV light photooxidative reactions are initiated which are damaging to biomolecules and affect the integrity of cells and tissues. Photooxidative damage plays a role in pathological processes and is involved in the development of disorders affecting the

資料

Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

質問

1–10/10 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか?

  3. Is Lycopene at this concetration dissolved in water for research on mice

    1 回答
    1. No, lycopene (L9879) can't be dissolved in water. The product is for lab research only, not for animal experiments.

      役に立ちましたか?

  4. How can I assess the condition of Product L9879, Lycopene, from its appearance?

    1 回答
    1. We advise against using the product if it becomes speckled or has a "salt and pepper" appearance. An acceptable range of colors is from dark purple to reddish brown to brown.

      役に立ちましたか?

  5. How can Product L9879, Lycopene, be dissolved?

    1 回答
    1. Lycopene dissolves in carbon disulfide (1 g/50 mL), boiling ether (1 g/3 L), boiling petroleum ether (1 g/12 L) or hexane at 0 °C (1 g/14 L). Lycopene is almost insoluble in methanol or ethanol, but is soluble in chloroform or benzene.

      役に立ちましたか?

  6. What is the method of preparation of Product L9879, Lycopene?

    1 回答
    1. Details of the method of preparation are considered proprietary information. The last solvent that the lycopene comes into contact with is methanol. However, the material is dried extensively, so little, if any, methanol should be present.

      役に立ちましたか?

  7. What is the solution stability of Product L9879, Lycopene?

    1 回答
    1. A solution prepared under argon, protected from light and stored at -20 °C is stable for up to 48 hours.  It is recommended to prepare solutions fresh each time and to prepare immediately before use.

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  8. What is the Department of Transportation shipping information for this product?

    1 回答
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      役に立ちましたか?

  9. What is the extinction coefficient of Lycopene, Product L9879?

    1 回答
    1. Extinction Coefficients: For samples dissolved in petroleum ether, E1% = 3450 (at 472 nm), 2250 (at 446 nm) and 3150 (at 505 nm).

      役に立ちましたか?

  10. Is Product L9879, Lycopene, of the Trans or Cis stereoforms?

    1 回答
    1. Based on the CAS number search in ACS database and the chemicals encyclopedia published by the Royal Society of Chemistry, this lycopene is an all-trans compound. The chemicals encyclopedia published by the Royal Society of Chemistry, 12th ed., Entry# 5650.

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レビュー

評価値なし

アクティブなフィルタ

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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