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安全性情報

I1286

Sigma-Aldrich

Icariin

≥94% (HPLC)

別名:

4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside

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About This Item

実験式（ヒル表記法）:
C33H40O15
CAS番号:
489-32-7
分子量:
676.66
MDL番号:
MFCD00210516
UNSPSCコード:
12352205
PubChem Substance ID:
329815347
NACRES:
NA.25
現在、価格および在庫状況を閲覧できません。

アッセイ

≥94% (HPLC)

色

light yellow to yellow

溶解性

DMSO: 50 mg/mL, clear, colorless to dark yellow

アプリケーション

metabolomics
vitamins, nutraceuticals, and natural products

保管温度

room temp

SMILES記法

COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2

InChI

1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1

InChI Key

TZJALUIVHRYQQB-XLRXWWTNSA-N

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関連するカテゴリー

詳細

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.[1]

アプリケーション

Icariin has been used:
  • in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats[2]
  • to test its analgesic effects on lower back pain (LBP) in rats[3]
  • as a potential treatment in osteoporosis condition in rats[4]
  • to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes[5]
  • as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells[6]

生物化学的／生理学的作用

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.
Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system.[1] It elicits anti-aging properties in unfertilized oocytes against age-related damage.[7] Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model.[8] It also serves as an excellent antidiabetic[9] and anti-atherosclerotic agent.[10] Icariin is an excellent anti-cancer agent.[1]

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

I1286-BULK:
I1286-VAR:
I1286-1G:
I1286-100MG:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
WXBF3544V
WXBF2114V
WXBD8605V
WXBD2828V
MKCJ1712

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Slide 1 of 8

1 of 8

Resveratrol A phenolic product found in both grape skins and wines.

Sigma-Aldrich

554325

Resveratrol

ヘスペレチン phyproof® Reference Substance

PHL89222

ヘスペレチン

センノシドA analytical standard

Supelco

68909

センノシドA

Puerarin analytical standard

Supelco

P5555

Puerarin

ベルベリン 塩化物フォーム

Sigma-Aldrich

B3251

ベルベリン 塩化物フォーム

Curcumin, Curcuma longa L. A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (IC₅₀ = 52 µM).

Sigma-Aldrich

239802

Curcumin, Curcuma longa L.

Icaritin phyproof® Reference Substance

PHL80478

Icaritin

Icariside I phyproof® Reference Substance

PHL83316

Icariside I

Feifei Tao et al.
Biochemical pharmacology, 85(6), 798-807 (2012-12-25)
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestine which involves overproduction of pro-inflammatory cytokines and excessive functions of inflammatory cells. However, current treatments for IBD may have potential adverse effects including steroid dependence, infections and lymphoma.
Bin Wu et al.
Journal of ethnopharmacology, 142(3), 746-753 (2012-06-13)
Icariin represents an important active component in Herba Epimedii, which is a famous Chinese herbal medicine that is widely used to treat some age-related diseases in oriental countries. The aim of this work was to investigate the effects of icariin
Qian Qian et al.
Journal of pharmaceutical and biomedical analysis, 66, 392-398 (2012-04-24)
In this work, the metabolite profiles of icariin in rat plasma were qualitatively investigated, and the possible metabolic pathways of icariin were subsequently proposed. After oral administration of icariin, rat plasma samples were collected and pretreated by protein precipitation. Then
Da Hye Kim et al.
Molecules (Basel, Switzerland), 22(6) (2017-06-14)
The therapeutic properties of Epimediumkoreanum are presumed to be due to the flavonoid component icariin, which has been reported to have broad pharmacological potential and has demonstrated anti-diabetic, anti-Alzheimer's disease, anti-tumor, and hepatoprotective activities. Considering these therapeutic properties of icariin
Jitian Li et al.
BioMed research international, 2020, 4670604-4670604 (2020-08-18)
To investigate whether icariin (ICA), a well-known medicine extracted from the stem and leaf of Epimedium brevicornum Maxim, had analgesic effect on lower back pain (LBP) in rats. In a puncture-induced LBP rat model, the severity of LBP was quantified
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質問

1–2/2 質問  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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