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安全性情報

I0908

Sigma-Aldrich

インスリン ヒト

meets USP testing specifications

別名:

Human insulin

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50 MG
￥43,200
250 MG
￥76,900

￥43,200

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50 MG
￥43,200
250 MG
￥76,900

About This Item

実験式（ヒル表記法）:
C257H383N65O77S6
CAS番号:
11061-68-0
分子量:
5807.57
EC Number:
234-279-7
MDL番号:
MFCD00131380
UNSPSCコード:
51183600
NACRES:
NA.21

￥43,200

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バルクの問い合わせ

由来生物

human

リコンビナント

expressed in Saccharomyces cerevisiae

認証

meets USP testing specifications

フォーム

solid

有効性

≥27.5 units/mg (dry)

テクニック

cell culture | mammalian: suitable

UniProtアクセッション番号

P01308

アプリケーション

pharmaceutical (small molecule)

保管温度

−20°C

InChI Key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

遺伝子情報

human ... INS(3630)

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関連するカテゴリー

生物化学的／生理学的作用

インスリンは、グルコ-ス、アミノ酸や脂肪酸の細胞内への取り込み、利用および貯蔵を調節し、グリコ-ゲン、タンパク質および脂肪の分解を阻害します。
膵島のβ細胞で産生される2本鎖ポリペプチドホルモンです。分子量は約5800 Daです。α鎖とβ鎖は、2本の鎖間ジスルフィド結合を解して連結しています。α鎖には、鎖内ジスルフィド結合が存在します。インスリンは、グルコ-ス、アミノ酸や脂肪酸の細胞内への取り込み、利用および貯蔵を調節し、グリコ-ゲン、タンパク質および脂肪の分解を阻害します。

その他情報

InChI: 1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

保管分類コード

11 - Combustible Solids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

I0908-50MG:
I0908-VAR:
I0908-250MG:
I0908-BULK:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
0000413834
0000413835
0000413834
0000413835
0000402792

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Marius Hervé et al.
Scientific reports, 12(1), 13191-13191 (2022-08-02)
We present experiments where extreme ultraviolet femtosecond light pulses are used to photoexcite large molecular ions at high internal energy. This is done by combining an electrospray ionization source and a mass spectrometer with a pulsed light source based on
Wei-Chieh Mu et al.
Nutrients, 10(7) (2018-07-20)
Aging is the main factor involved in the onset of degenerative diseases. Dietary protein restriction has been shown to increase the lifespan of rodents and improve metabolic phenotype. Branched-chain amino acids (BCAA) can act as nutrient signals that increase the
Benoit You et al.
EBioMedicine, 51, 102574-102574 (2019-12-27)
In colorectal cancer, hPG80 (progastrin) is released from tumor cells, promotes cancer stem cells (CSC) self-renewal and is detected in the blood of patients. Because the gene GAST that encodes hPG80 is a target gene of oncogenic pathways that are
Michael J Abrams et al.
eLife, 10 (2021-12-08)
Can limb regeneration be induced? Few have pursued this question, and an evolutionarily conserved strategy has yet to emerge. This study reports a strategy for inducing regenerative response in appendages, which works across three species that span the animal phylogeny.
Yan Gu et al.
Nature communications, 12(1), 6711-6711 (2021-11-20)
Cancer stemness represents a major source of development and progression of colorectal cancer (CRC). c-Met critically contributes to CRC stemness, but how c-Met is activated in CRC remains elusive. We previously identified the lipolytic factor ABHD5 as an important tumour
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質問

1–5/5 質問  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      役に立ちましたか？

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      役に立ちましたか？

  3. Is this product sterile or not ? Can this be filtered using a 0.22uM filter after being added in the media ?

    1 回答

    1. This product is not sterile. It may be filter sterilized using a low protein binding membrane having a 0.2 μm pore size. Typically, the stock solution is filter sterilized when prepared and added aseptically to the media.
      See the link below to review the product datasheet for the bovine insulin products. While not the same biological source, the general information does apply to the human source product.

      Product Datasheet:
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/132/262/i6634pis.pdf

      役に立ちましたか？

  4. What is the solublity and solution stability for Product I0908, Insulin?

    1 回答

    1. As Product I0908 - Insulin human meets USP specifications, we only report out the USP testing results.  In the USP method, Insulin is dissolved in 0.01N HCl.  Insulin is readily soluble (10-20 mg/ml) in weak acids.For Product I2643, recombinant human insulin, we indicate the following storage conditions. A stock solution can be stored frozen at -20°C in single-use aliquots. Freeze-thaw cycles should be avoided. Alternatively, it can be stored for up to 12 months at 2-8°C, if it is sterile filtered through a low protein binding membrane or if it contains a suitable bacteriostat, such as 0.1% thimerosal or sodium azide.

      役に立ちましたか？

  5. What is the Department of Transportation shipping information for this product?

    1 回答

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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