EPS002

MS-275

A HDAC1 and HDAC3 inhibitor

• 別名: 3-ピリジニルメチル [[4-[[(2-アミノフェニル)アミノ]カルボニル]フェニル]メチル]カルバマート, N-(2-アミノフェニル)-4-[N-(ピリジン-3イルメトキシカルボニル)アミノメチル]ベンズアミド
• 実験式（ヒル表記法）: C₂₁H₂₀N₄O₃
• CAS番号: 209783-80-2
• 分子量: 376.41
• NACRES: NA.41
• PubChem Substance ID: 329799578
• UNSPSC Code: 12352200
• MDL number: MFCD03453552
• Assay: ≥99%

特性

• assay: ≥99%
• solubility: DMSO: 38 mg/mL
• storage temp.: −20°C
• SMILES string: Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2
• InChI: 1S/C21H20N4O3/c22-18-5-1-2-6-19(18)25-20(26)17-9-7-15(8-10-17)13-24-21(27)28-14-16-4-3-11-23-12-16/h1-12H,13-14,22H2,(H,24,27)(H,25,26)
• InChI key: INVTYAOGFAGBOE-UHFFFAOYSA-N
• Gene Information: human ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)

詳細

General description

Preferentially inhibits HDAC1 (IC₅₀=300 nM) over HDAC3 (IC₅₀=8 μM). Has no inhibitory activity towards HDAC8 (IC₅₀>100 μM).

Application

MS-275 has been used as a histone deacetylase-1 inhibitor.

Biochem/physiol Actions

HDAC阻害剤で、抗増殖性です。

安全性情報

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H360
• pcodes: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 1A
• 保管分類: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable