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由来生物
goat
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
lyophilized powder
化学種の反応性
human
テクニック
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... EFNA4(1945)
詳細
By ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human ephrin-A5 and no cross-reactivity with recombinant mouse ephrin-A1, mouse ephrin-A2, human ephrin-A3, mouse ephrin-B1, mouse ephrin-B2, and mouse ephrin B3.
免疫原
recombinant human ephrin-A4, extracellular domain, expressed in NSO cells.
生物化学的／生理学的作用
Ephrin A4 binds to EPH receptor A4, a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. The ephrin-A and ephrin-B ligands and regulate developmental events, particularly those of the nervous system. EphrinA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 receptor correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.
物理的形状
凍結乾燥品(0.2 μmフィルターろ過済みPBS溶液)。
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保管分類コード
10 - Combustible liquids
最新バージョンのいずれかを選択してください：
Kathryn M Munro et al.
PloS one, 8(2), e55948-e55948 (2013-02-08)
The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as
Kohji Miyazaki et al.
BMC clinical pathology, 13(1), 19-19 (2013-06-07)
Erythropoietin-producing hepatocellular (Eph) receptor, consisting of a family of receptor tyrosine kinases, plays critical roles in tumour development and is considered an attractive target for cancer therapy. Tumour samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy.
Manish Tandon et al.
Expert opinion on therapeutic targets, 15(1), 31-51 (2010-12-15)
High mortality rates with cancers warrant further development of earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. EphA2 overexpression in
アクティブなフィルタ
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