This product is water-soluble and can be dissolved in water-based solvents, including artificial cerebrospinal fluid (aCSF). The solubility in water has been tested at concentrations > 5 mg/mL. The material is also soluble in DMSO at approximately 3 mg/mL and ethanol at approximately 2 mg/mL. Prepared solutions may be stored for approximately 24 hours at 4 °C, protected from light.
D054
R(+)-SCH-23390 塩酸塩
≥98% (HPLC), dopamine receptor antagonist, solid
別名:
R(+)-7-クロロ-8-ヒドロキシ-3-メチル-1-フェニル-2,3,4,5-テトラヒドロ-1H-3-ベンゾアゼピン 塩酸塩
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
5 mg | カートの在庫状況を確認する | ￥30,700 |
10 mg | 出荷予測2026年5月25日from市川市大町368 | ￥41,500 |
25 mg | カートの在庫状況を確認する | ￥107,000 |
100 mg | カートの在庫状況を確認する | ￥223,000 |
この商品について
実験式（ヒル表記法）:
C17H18ClNO · HCl
CAS番号:
分子量:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light
製品名
R(+)-SCH-23390 塩酸塩, ≥98% (HPLC), solid
Quality Segment
assay
≥98% (HPLC)
form
solid
optical activity
[α]/D +32.1°, c = 1 in DMF(lit.)
storage condition
desiccated, protect from light
color
white
solubility
H2O: >5 mg/mL
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Gene Information
human ... DRD1(1812)
Application
R（+）-SCH-23390塩酸塩は、下記の用途で使用されています：
- 感作におけるD1受容体の役割を調べるため、実験用ラットの腹腔内に注射
- 頭蓋内投与用のD1受容体に選択的なアンタゴニストとして
- 魚類の学習能力に対する影響を調べるためのD1受容体アンタゴニストとして
Biochem/physiol Actions
R（+）-SCH-23390塩酸塩は、選択的なD1ドーパミン受容体アンタゴニストです。これは、5-ヒドロキシトリプタミン2（5-HT2）および5-HT1Cセロトニン受容体サブタイプに対し、in vitroで高い結合能力を示します。投与後のR（+）-SCH-23390の半減期は、約25分です。これは、常同行動に対する抑制作用およびカタレプシー惹起作用を持つことが知られています。また、自発運動量に対しても抑制作用を示します。
Features and Benefits
この化合物は、Handbook of Receptor Classification and Signal Transduction（受容体分類およびシグナル伝達ハンドブック）のDopamine Receptors（ドーパミン受容体）およびPotassium Channels（カリウムチャンネル）のページに記載されています。ハンドブックのその他のページをご覧になるには、こちらをクリックしてください。
Legal Information
Schering-Ploughの許諾を得て販売しています。
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当該品目 | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay - |
| form solid | form crystalline | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage condition desiccated, protect from light | storage condition desiccated, protect from light | storage condition desiccated | storage condition - |
| solubility H2O: >5 mg/mL | solubility H2O: >5 mg/mL, aqueous base: soluble (unstable) | solubility H2O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL | solubility H2O: 3.7 mg/mL, aqueous base: unstable, ethanol: soluble |
| color white | color white | color white to light tan | color tan |
保管分類
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Can you dissolve Product D054, R(+)-SCH-23390 hydrochloride in aCSF?
1 回答-
役に立ちましたか？
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What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?
1 回答-
Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.
役に立ちましたか？
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Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?
1 回答-
The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.
役に立ちましたか？
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What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?
1 回答-
The melting point is 247-248°C.
役に立ちましたか？
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How does the storage temperature relate to shipping conditions?
1 回答-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
役に立ちましたか？
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How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?
1 回答-
The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.
役に立ちましたか？
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Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?
1 回答-
Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.
役に立ちましたか？
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What is the Department of Transportation shipping information for this product?
1 回答-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
役に立ちましたか？
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