Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain). Product C9983, Creatine Kinase BB Fraction Human, refers to the brain isozyme.
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詳細
50%グリセロール、10 mMビス-Tris-HClを含むTrisバッファー、0.5 mM DTTおよび0.5 mM EDTAを含有する溶液。
アプリケーション
Human creatine kinase BB fraction has been used to investigate the survival benefit of the late percutaneous coronary intervention in patients after acute myocardial infarction. Human creatine kinase BB fraction has also been used in a study to analyze protein oxidations and resultant loss of function.
生物化学的／生理学的作用
The product is used as a control in monitoring levels in cerebrospinal fluid by ELISA. Creatine kinase (CK) BB is a member of the CK gene family and is a cytosolic CK isoform present in the brain. The molecular mass is found to be 35-50 kDa. CKs catalyze the reversible transfer of a phosphoryl group between ATP and creatine. It plays an important role in the regulation of ATP level in neural cells. Therefore, a decrease in CK BB activity is one of the biochemical markers of the CNS cell damage in age-related neurodegenerative diseases such as Alzheimer′s disease, Pick′s disease, and Lewy body dementia.[1]
単位の定義
1 unitは、37°C、1分間で、クレアチンリン酸からADPに1.0 μmoleのリン酸を転移します(共役反応により生成したNADHの1等モル量として340 nmで測定)。
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C9983-BULK:
C9983-100UG-PW:
C9983-100UG:
C9983-VAR:
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Loïc Dayon et al.
Analytical chemistry, 80(8), 2921-2931 (2008-03-04)
A new 6-plex isobaric mass tagging technology is presented, and proof of principle studies are carried out using standard protein mixtures and human cerebrospinal fluid (CSF) samples. The Tandem Mass Tags (TMT) comprise a set of structurally identical tags which
T Talvik et al.
Acta paediatrica (Oslo, Norway : 1992), 84(10), 1183-1187 (1995-10-01)
Creatine kinase isoenzyme BB was determined in cerebrospinal fluid (CSF) in 79 preterm neonates using an original enzyme-linked immunosorbent assay. The criterion for inclusion was an Apgar score of 7 or less at 5 min of life. Neurological examination was
M Aksenov et al.
Journal of neurochemistry, 74(6), 2520-2527 (2000-05-23)
Creatine kinase (CK) BB, a member of the CK gene family, is a predominantly cytosolic CK isoform in the brain and plays a key role in regulation of the ATP level in neural cells. CK BB levels are reduced in
Bozidarka Knezević et al.
Bosnian journal of basic medical sciences, 9(1), 54-58 (2009-03-17)
The impact of late percutaneous coronary intervention (PCI) in the patients after acute myocardial infarction (AMI) on long term mortality remains to be established. At currently, thrombolysis is accepted as standard therapy when PCI is not immediately available. However, PCI
Paul D Hamilton et al.
Biochemistry and biophysics reports, 22, 100748-100748 (2020-03-11)
Creatine kinase (CK) is an energy storage enzyme that plays an important role in energy metabolism. CK/phosphocreatine functions as an energy buffer and links ATP production sites with ATP utilization sites. Several key mutations in the αA-crystallin (cryaa) and αB-crystallin
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What does the "BB" stand for in "Creatine Kinase BB Fraction Human", product C9983?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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