This human serum used to prepare this product is from a pool of approximately 50 donors.
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詳細
The complement serum standard human is suitable for the determination of CH50 and AP50 complement activities. This allows for a test of the complement activity on the capacity of the serum to lyse red blood cells in vitro and can be used in procedures for genotyping DNA samples of the complement system.
アプリケーション
Complement Serum Standard human has been used as a positive control to study the role of the complement system in immunological demyelination of the spinal cord from mammals.[1]
生物化学的／生理学的作用
The complement system is an important constituent of innate immunity.[2] It participates in the first line of defense against microbial infections, altered host cells, and removal of immune complexes and injured cells. The complement system comprises more than thirty components such as the plasma proteins produced by the liver, membrane proteins expressed on the cell surface, cytokines, and hormones.[2][3] The complement proteins come together to opsonize the pathogens and initiate a cascade of inflammatory responses serving the immune cells to fight the infection and maintain homeostasis.[2]
物理的形状
0.22 μmフィルターで処理した溶液(約18 mMクエン酸、約22 mMブドウ糖、約3 mMリン酸、約13 mMカルシウム含有)。
免責事項
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
C9473-1ML:
C9473-VAR:
C9473-1ML-LBL:
C9473-BULK:
C9473-1ML-PW:
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J K Dyer et al.
Spinal cord, 43(7), 417-425 (2005-05-18)
Specificity of serum complement component to elicit immunological demyelination. To assess the role of complement components and pathways in experimental immunological demyelination of the adult rat spinal cord. ICORD, University of British Columbia, Vancouver, Canada. We used 32 adult male
Marina Noris et al.
Seminars in nephrology, 33(6), 479-492 (2013-10-29)
Complement is an important component of the innate immune system that is crucial for defense from microbial infections and for clearance of immune complexes and injured cells. In normal conditions complement is tightly controlled by a number of fluid-phase and
Nicolas S Merle et al.
Frontiers in immunology, 6, 262-262 (2015-06-18)
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger signals. The subsequent cascade of
Risk Alleles in CFH and ARMS2 Are Independently Associated with Systemic Complement Activation in Age-related Macular Degeneration.
Smailhodzic D., et al.
Ophthalmology (2011)
P J Francis et al.
Journal of medical genetics, 46(5), 300-307 (2008-11-19)
Age related macular degeneration (AMD) is a leading cause of blindness. AMD is a complex disorder caused by genetic and environmental factors in which single nucleotide polymorphisms (SNPs) in the genes CFH and LOC387715/HTRA1/ARMS2 have prognostic importance for progression to
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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