The molecular weight for Product C8195, Complement C4 from human serum, is 205,000 daltons as described in Complement: A Practical Approach, A.W. Dodds and R.B. Sim, Eds., p. 2, 1997.
C8195
補体C4 ヒト血清由来
≥300,000 C4H50 units/mg protein
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
|---|---|---|
0.1 mg | カートの在庫状況を確認する | ￥74,600 |
この商品について
Form:
solution
Biological source:
human serum
General description
Complement C4 is mapped to human chromosome 6p21.33. It exists in two isoforms as c4A and c4B. C4 is a 200 kDa protein belonging to α2 macroglobulin (α2M) family. It undergoes posttranslational modification like sulfation and glycosylation and finally proteolysis to become a mature protein.
Application
Complement C4 from human serum has been used in mannose binding lectin (MBL) complex assay of serum samples and in MBL-associated serine proteases based C4 activation assay of plasma samples.
Biochem/physiol Actions
補体C4の欠乏は全身性エリテマトーデス(SLE)や、その他の自己免疫疾患の誘発と相関性を示すことが顕著に認められています。
Complement C4 serves a primary role in the classical and lectin pathways of the complement system and provides protection against bacterial pathogens. C4 polymorphisms have been used in research to study their associations with the hemolytic and antibacterial ability of the classical pathway.
Variation in the copy number of the complement C4 gene alters the complement c4A and c4B levels in age-related macular degeneration (AMD) and increases risk of developing schizophrenia.
Physical form
PBS(pH 7.2)溶液。
Other Notes
より詳細な情報につきましては、www.sigma-aldrich.com/enzymeexplorerの補体経路をご覧ください。
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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当該品目 | |||
|---|---|---|---|
| technique(s) activity assay: suitable | technique(s) - | technique(s) activity assay: suitable | technique(s) activity assay: suitable |
| biological source human serum | biological source - | biological source human serum | biological source human |
| form solution | form liquid | form solution | form liquid |
| specific activity ≥300,000 C4H50 units/mg protein | specific activity >3X105 C4H50 units/mg protein | specific activity >100,000 C5H50 units/mg protein | specific activity - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. | UniProt accession no. |
保管分類
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the molecular weight of Product C8195, Complement C4 from human serum?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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