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アッセイ
≥98% (HPLC)
フォーム
solid
色
tan
溶解性
DMSO: ≥10 mg/mL
オーガナイザー
AstraZeneca
保管温度
2-8°C
InChI
1S/C24H21N3O5S/c28-23-16-33-24(29)26(23)21(7-4-17-10-12-25-13-11-17)15-32-22-8-5-18(6-9-22)19-2-1-3-20(14-19)27(30)31/h1-3,5-6,8-14,21H,4,7,15-16H2
InChI Key
VQEHBLGYANQWEA-UHFFFAOYSA-N
アプリケーション
AZ11645373 is a selective and potent human P2X7 purinoceptor antagonist. AZ11645373 has been used in the rhesus macaque monkey to elucidate the mechanisms and pharmacological interventions of P2X7 receptor-related diseases.
生物化学的／生理学的作用
AZ11645373はヒトP2X7プリン受容体に対する選択的かつ強力なアンタゴニストです。ヒトP2X7受容体の阻害に関するKB値の範囲は5~20 nMです。これは、ラットP2X7受容体応答に対するインヒビタ-としての効果と比べると500分の1の値です。
特徴および利点
This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
ターゲットの組織
Respiratory system
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
A7231-25MG:
A7231-5MG:
A7231-BULK:
A7231-VAR:
最新バージョンのいずれかを選択してください：
L Stokes et al.
British journal of pharmacology, 149(7), 880-887 (2006-10-13)
The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified a novel set of cyclic imide compounds that inhibited P2X(7) receptor-mediated dye
Acetylation of SUMO1 Alters Interactions with the SIMs of PML and Daxx in a Protein-Specific Manner.
Xavier H Mascle et al.
Structure (London, England : 1993), 28(2), 157-168 (2019-12-28)
The interactions between SUMO proteins and SUMO-interacting motif (SIM) in nuclear bodies formed by the promyelocytic leukemia (PML) protein (PML-NBs) have been shown to be modulated by either phosphorylation of the SIMs or acetylation of SUMO proteins. However, little is
Helen J Bradley et al.
British journal of pharmacology, 164(2b), 743-754 (2011-04-05)
The human P2X7 (hP2X7) receptor exhibits striking pharmacological differences from its rodent counterparts, particularly in terms of its antagonist profile. Here, we characterized the functional and pharmacological properties of the rhesus macaque monkey P2X7 (rmP2X7) receptor in comparison with the
Gloria Lopez-Castejon et al.
Journal of immunology (Baltimore, Md. : 1950), 185(4), 2611-2619 (2010-07-20)
The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under clinical trials for rheumatoid arthritis. Anti-inflammatory actions of P2X(7)R antagonists are considered to result from inhibition of P2X(7)R-induced release of
K Wareham et al.
British journal of pharmacology, 157(7), 1215-1224 (2009-06-26)
P2X receptors are widely expressed in cells of the immune system with varying functions. This study sought to characterize P2X receptor expression in the LAD2 human mast cell line and human lung mast cells (HLMCs). Reverse transcriptase polymerase chain reaction
資料
We offer many products related to P2X ion channel family receptors for your research needs.
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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