A0980

AM281

≥98% (HPLC)

• 別名: AM 281
• 実験式（ヒル表記法）: C₂₁H₁₉Cl₂IN₄O₂
• CAS番号: 202463-68-1
• 分子量: 557.21
• MDL番号: MFCD01861180
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724384
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white
• 溶解性: DMSO: >6 mg/mL; H₂O: insoluble
• 保管温度: 2-8°C
• SMILES記法: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCOCC4
• InChI: 1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)
• InChI Key: AJFFBPZYXRNAIC-UHFFFAOYSA-N
• 遺伝子情報: rat ... Cnr1(25248)

詳細

アプリケーション

AM281 has been used as a cannabinoid 1 receptor antagonist:

• to study its effects on memory deficit following naloxone-precipitated morphine withdrawal in mice
• to study the role of CB1 receptor system in modulating acetaldehyde-induced effects in rats during the extinction-, relapse-, and conflict-experiments
• to study its effect on scopolamine-induced memory deficit using object recognition paradigm
• to block synthetic cannabinoid (HU210)-induced analgesia in the ventrolateral orbital cortex (VLO) to evaluate the effect of CB1 receptors on the VLO modulation of pain

生物化学的／生理学的作用

AM281 is less lipophilic compared to its analog SR 141716A, a cannabinoid receptor antagonist. AM281 may prevent memory deficit post morphine withdrawal by inhibiting cannabinoid receptors in mice.

Potent and selective CB₁ cannabinoid receptor antagonist/inverse agonist

特徴および利点

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300,H315,H319,H335
• 注意書き: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges