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アッセイ
≥97.0% (HPLC)
フォーム
powder or crystals
不純物
≤7% water
アプリケーション
metabolomics
vitamins, nutraceuticals, and natural products
SMILES記法
Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2
InChI
1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChI Key
FURUXTVZLHCCNA-AWEZNQCLSA-N
詳細
Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.[1]
アプリケーション
Liquiritigenin has been used:
- to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer[2]
- as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract[3]
- as a potential antiviral drug against hepatitis C virus (HCV) infection[4]
生物化学的／生理学的作用
Liquiritigenin displays anti-diabetic[1] and choleretic[5] properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS).[6] Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components.[7] It is a selective estrogen receptor β agonist[8] cells.[9] Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.[10]
包装
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
78825-10MG:
78825-50MG:
78825-BULK:
78825-VAR:
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Rui Ting Liu et al.
European journal of pharmacology, 669(1-3), 76-83 (2011-08-30)
The present paper is to examine whether liquiritigenin is able to attenuate the Alzheimer's-like learning and memory deficits in a transgenic (Tg) mouse model that over-expresses amyloid protein precursor (APP), and explores the underlying mechanisms. Consistent with our previous observations
Shi-ping Zhang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47(4), 693-701 (2009-01-20)
Liquiritigenin is a flavanone existed in Radix glycyrrhizae. The objective of this study is to explore the effects of liquiritigenin on SMMC-7721 cells and its possible mechanism. The viability of liquiritigenin treat cells was decreased in a dose-dependent manner assayed
Gangadhara R Sareddy et al.
Molecular cancer therapeutics, 11(5), 1174-1182 (2012-03-24)
Gliomas are the most common and devastating central nervous system neoplasms. A gender bias exists in their development: females are at lower risk than males, implicating estrogen-mediated protective effects. Estrogen functions are mediated by two estrogen receptor (ER) subtypes: ERα
Eun Mi Choi
International immunopharmacology, 12(1), 139-143 (2011-11-26)
Liquiritigenin is one of the flavonoids present in Glycyrrhizae radix. In the present study, the effects of liquiritigenin on the function of osteoblastic MC3T3-E1 cells were studied. Liquiritigenin caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis
Eun-Ju Yang et al.
Neurotoxicology, 39, 114-123 (2013-09-10)
The progressive death of neurons following exposure to high concentrations of glutamate leads to loss of learning and memory and pathogenesis of neurodegenerative disorders. Therefore, identification of drugs that protect against glutamate-mediated neuronal cell death is a good strategy for
アクティブなフィルタ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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