51060

グアノシン 5′-二リン酸 二ナトリウム塩

≥90% (HPLC)

• 別名: 5′-GDP-Na₂
• 実験式（ヒル表記法）: C₁₀H₁₃N₅Na₂O₁₁P₂
• CAS番号: 7415-69-2
• 分子量: 487.16
• EC Number: 231-026-2
• MDL番号: MFCD00084665
• UNSPSCコード: 41106305
• PubChem Substance ID: 57651304
• NACRES: NA.51

特性

• 由来生物: Porcine brain; microbial (Corynebacterium sp); synthetic
• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• 形状: powder
• 溶解性: H₂O: 50 mg/mL, clear, colorless
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: [Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
• InChI Key: LTZCGDIGAHOTKN-LGVAUZIVSA-L

詳細

詳細

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

アプリケーション

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

Guanosine 5′-diphosphate disodium salt has been used:

• in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
• in screening of fluorescence emission of hypocrellin A-zinc complex
• as a component of assay buffers in the autoradiography of mice brain sections

生物化学的／生理学的作用

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)