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Merck
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主要文書

224M-1

Sigma-Aldrich

Beta-Catenin (14) Mouse Monoclonal Antibody

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41
現在、価格および在庫状況を閲覧できません。

由来生物

mouse

品質水準

100
500

結合体

unconjugated

抗体製品の状態

culture supernatant

抗体製品タイプ

primary antibodies

クローン

14, monoclonal

詳細

For In Vitro Diagnostic Use in Select Regions (See Chart)

フォーム

buffered aqueous solution

交差性

human

包装

vial of 0.1 mL concentrate (224M-14)
vial of 0.5 mL concentrate (224M-15)
bottle of 1.0 mL predilute (224M-17)
vial of 1.0 mL concentrate (224M-16)
bottle of 7.0 mL predilute (224M-18)

メーカー／製品名

Cell Marque®

濃度

1.0-5.0 μg/mL (predilute)
25-125 μg/mL (concentrate)

テクニック

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

アイソタイプ

IgG1

コントロール

fibromatosis of breast

輸送温度

wet ice

保管温度

2-8°C

視覚化

membranous, nuclear

関連するカテゴリー

詳細

Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.

品質


IVD
IVD
IVD
RUO

関連事項

Beta-Catenin Positive Control Slides, Product No. 224S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: [email protected]

法的情報

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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試験成績書（COA）

Lot/Batch Number
0000405668
0000401998
0000373292
0000373273
0000365817

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文書ライブラリにアクセスする

C Li et al.
The American journal of pathology, 153(3), 709-714 (1998-09-15)
Aggressive fibromatosis is a monoclonal proliferation of spindle (fibroblast-like) cells. A subset of lesions contain somatic truncating adenomatous polyposis coli (APC) gene mutations, and all of the lesions contain an elevated beta-catenin protein level. A major function of APC is
Ejaz Butt et al.
F1000Research, 8, 613-613 (2019-05-02)
Background: Ependymomas are glial tumors derived from differentiated ependymal cells. In contrast to other types of brain tumors, histological grading is not a good prognostic marker for these tumors. In order to determine genomic changes in an anaplastic ependymoma, we
B A Alman et al.
The American journal of pathology, 151(2), 329-334 (1997-08-01)
Sporadic aggressive fibromatosis (also called desmoid tumor) is a monoclonal proliferation of spindle (fibrocyte-like) cells that is locally invasive but does not metastasize. A similarity to abdominal fibromatoses (desmoids) in familial adenomatous polyposis and a cytogenetic study showing partial deletion
Elizabeth Montgomery et al.
The American journal of surgical pathology, 26(10), 1296-1301 (2002-10-03)
Although separating gastrointestinal stromal tumor (GIST) from mesenteric fibromatosis and sclerosing mesenteritis is clinically important, this distinction sometimes poses problems for practicing pathologists. In the STI571 (Gleevec, Imatinib) era, the problem may be further compounded when protocol-driven staining for CD117
Susan C Abraham et al.
Human pathology, 33(1), 39-46 (2002-02-02)
Fibromatoses of the breast are nonmetastasizing tumors, but can be infiltrative and locally recurrent. Breast fibromatoses are rare, and their specific genetic alterations have not been elucidated. However, their occasional occurrence in patients with familial adenomatous polyposis (FAP) and their
関連する文献をすべて表示

資料

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

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