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安全性情報

14370

Sigma-Aldrich

ビリルビン

purum, ≥95.0% (UV)

別名:

Bile pigment, Hemetoidin

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About This Item

実験式（ヒル表記法）:
C33H36N4O6
CAS番号:
635-65-4
分子量:
584.66
Beilstein:
74376
EC Number:
211-239-7
MDL番号:
MFCD00005499
UNSPSCコード:
12352202
PubChem Substance ID:
57647150
NACRES:
NA.25
現在、価格および在庫状況を閲覧できません。

グレード

purum

アッセイ

≥95.0% (UV)

フォーム

powder

強熱残分

≤0.5%

SMILES記法

CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

InChI Key

BPYKTIZUTYGOLE-IFADSCNNSA-N

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関連するカテゴリー

詳細

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.[1]

アプリケーション

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I[2]. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.[3]

生物化学的／生理学的作用

ビリルビン全体のうちの99%を十分に上回る量がアルブミン結合体として輸送されます。ビリルビンの異常高値により重度の神経障害が起こり得ますが、わずかな高値は酸化ストレスからの保護につながります。
Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher.[1] This bile pigment has both antioxidant and toxic properties.[1] It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs).[4] It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases.[5][6] Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease.[7] It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.[7]

アナリシスノート

λmax. ∼453 nm, mol. absorption >56100 (chloroform)

保管分類コード

11 - Combustible Solids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

14370-250MG:
14370-1G:
14370-5G:
14370-BULK:
14370-VAR:

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number
BCCL6435
BCCJ8864
BCCL1458
BCCH1649
BCCF8504

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Slide 1 of 4

1 of 4

トリドデカン酸グリセリル ≥99%

Sigma-Aldrich

T4891

トリドデカン酸グリセリル

イントラリピッド 20%, emulsion

Sigma-Aldrich

I141

イントラリピッド

ヘモグロビン A0, 鉄安定化 ヒト lyophilized powder

Sigma-Aldrich

H0267

ヘモグロビン A0, 鉄安定化 ヒト

ビリベルジンレダクターゼA ヒト recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous solution

Sigma-Aldrich

B3687

ビリベルジンレダクターゼA ヒト

Kenichiro Yamashita et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 765-767 (2004-02-24)
Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now show that administration of biliverdin has a salutary effect in organ transplantation. A brief course
Yen-Wen Wu et al.
Acta Cardiologica Sinica, 36(6), 649-659 (2020-11-26)
The rapid diagnosis of acute myocardial infarction (AMI) is a clinical and operational priority in emergency departments. Serial serum levels of cardiac biomarkers play a crucial role in the evaluation of patients presenting with acute chest pain, so that an
Stefan W Ryter et al.
American journal of respiratory cell and molecular biology, 36(2), 175-182 (2006-09-19)
Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentially relates
U Warttinger et al.
Analytical and bioanalytical chemistry, 408(28), 8241-8251 (2016-10-22)
Heparins are widely used anticoagulant drugs. The current monitoring practice for heparin in plasma, such as the chromogenic anti-factor Xa assay, relies on heparin-triggered activation of antithrombin, an inhibitor of coagulation proteases. Such assays are not applicable to the detection
Robert Ollinger et al.
Cell cycle (Georgetown, Tex.), 6(1), 39-43 (2007-01-25)
We have recently shown that the natural bile pigment bilirubin has antiproliferative effects on vascular smooth muscle cells (VSMCs). Bilirubin is the end product of heme catabolism mediated by heme oxygenases and has for decades been considered a toxic waste
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質問

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 回答

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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