2011

Bilirubin

solid, bile pigment, Calbiochem^®

• 別名: Bilirubin
• 実験式（ヒル表記法）: C₃₃H₃₆N₄O₆
• CAS番号: 635-65-4
• 分子量: 584.66
• MDL番号: MFCD00005499
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Bilirubin, Principal pigment of bile and one of the major end products of hemoglobin decomposition.
• 品質水準: 100
• 詳細: RTECS - DU3038000; Merck USA index - 14, 1218
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: red-brown
• 溶解性: chloroform: 1 mg/mL; alkaline solution: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• SMILES記法: [nH]1c(c(c(c1\C=C4/NC(=O)C(=C/4C)C=C)C)CCC(=O)O)Cc2[nH]c(c(c2CCC(=O)O)C)\C=C3/NC(=O)C(=C/3C=C)C
• InChI: 1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-
• InChI Key: BPYKTIZUTYGOLE-IFADSCNNSA-N

詳細

詳細

Bilirubin is an orange-yellow bile pigment and one of the major end products of hemoglobin decomposition. It contains conjugated double bonds and reactive hydrogen atoms. In adults, the upper limit of the normal range of bilirubin is >1mg/dL. Serum levels of bilirubin in healthy newborns are less than 15 mg/dl. This product corresponds to the unconjugated form.

生物化学的／生理学的作用

Bilirubin is reported to cross the blood-brain barrier and exert significant antioxidant effects in the brain. This pigment aids in coloration in the various forms of jaundice. Bilirubin levels act as biomarkers in liver and blood disorders. Unconjugated form of bilirubin at lower levels serves as a physiological antioxidant. However, increased concentration of bilirubin is toxic and leads to neonatal hyperbilirubinemia in neonates.

再構成

Unstable in basic solutions; reconstitute just prior to use.

その他情報

Extinction coefficient (454 nm, CHCl₃):59,100-62,300 M^-1cm^-1.
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary Target

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable