PHR1765

D-シクロセリン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: (R)-4-アミノ-3-イソオキサゾリドン, 4-アミノ-3-イソオキサゾリジノン
• 実験式（ヒル表記法）: C₃H₆N₂O₂
• CAS番号: 68-41-7
• 分子量: 102.09
• Beilstein: 80798
• EC Number: 200-688-4
• MDL番号: MFCD00005353
• UNSPSCコード: 12352209
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1158005
• APIファミリー: cycloserine
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• mp: 147 °C (dec.) (lit.)
• アプリケーション: pharmaceutical
• フォーマット: neat
• 保管温度: -10 to -25°C
• SMILES記法: N[C@@H]1CONC1=O
• InChI: 1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)/t2-/m1/s1
• InChI Key: DYDCUQKUCUHJBH-UWTATZPHSA-N

詳細

詳細

Cycloserine is a broad-spectrum antibiotic commonly produced by certain strains of Streptomyces orchidaceus or S. garphalus.[1] It is used as a second-line drug treatment for multiple drug-resistant strains of Mycobacterium tuberculosis.[2][3]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Cycloserine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by high performance liquid chromatography.[3][4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

作用機序：細胞壁生合成を阻害（D-アラニン ペプチド結合形成）。また、D-アラニンからL-アラニンへの変換を妨げます。静菌性。
NMDAグルタミン酸作動性受容体のグリシン修飾部位の半アゴニスト；グラム陽性細菌に対する抗生物質。
抵抗性機序：D-アラニン輸送の妨害

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA8432 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable