PHR1365

ラミブジン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: ラミブジン, 2',3'-ジデオキシ-3'-チアシチジン, 3TC, Epivir, Epivir-HBV, Heptovir, Zeffix
• 実験式（ヒル表記法）: C₈H₁₁N₃O₃S
• CAS番号: 134678-17-4
• 分子量: 229.26
• MDL番号: MFCD00869739
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823344
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 802; traceable to Ph. Eur. Y0000425; traceable to USP 1356836
• APIファミリー: lamivudine
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2
• InChI: 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
• InChI Key: JTEGQNOMFQHVDC-NKWVEPMBSA-N

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lamivudine is a synthetic nucleoside analog that shows potential action against human immunodeficiency virus (HIV). It is one of the front line therapies used to treat HIV infection.[1]

アプリケーション

Lamivudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations[2][3][4] and serum samples[1] by chromatography[2][3][4][1] and spectrophotometry[2][3] techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

ラミブジンは、強力なヌクレオシドアナログ逆転写酵素インヒビター(nRTI)です。

ラミブジンは、強力なヌクレオシドアナログ逆転写酵素インヒビター(nRTI)です。シチジンのアナログで、HIV逆転写酵素の両タイプ(1と2)ならびにB型肝炎逆転写酵素を阻害することができます。活性型になる前に、三リン酸塩にリン酸化される必要があります。3TC三リン酸塩も、細胞DNAポリメラーゼを阻害します。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA1469 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361
• 注意書き: P201 - P308 + P313
• 危険有害性の分類: Repr. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable