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PHR1294

Supelco

クロルヘキシジン 二グルコン酸塩 溶液

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

1,6-ビス(N5-[p-クロロフェニル]-N1-ビグアニド)ヘキサン; 1,1′-ヘキサメチレンビス(5-[p-クロロフェニル]ビグアニド)

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1 G
¥12,700

¥12,700


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1 G
¥12,700

About This Item

CAS番号:
MDL番号:
UNSPSCコード:
41116107
PubChem Substance ID:
NACRES:
NA.24

¥12,700


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グレード

certified reference material
pharmaceutical secondary standard

品質水準

認証

traceable to Ph. Eur. C1510000/1520000
traceable to USP 1111001/1111103

詳細

Chlorhexidine digluconate solution at approximately 20% in water

APIファミリー

chlorhexidine

CofA

current certificate can be downloaded

アプリケーション

pharmaceutical (small molecule)

フォーマット

single component solution

保管温度

2-8°C

SMILES記法

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

InChI Key

YZIYKJHYYHPJIB-UUPCJSQJSA-N

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詳細

品質管理の認定を受けた製品番号医薬品の2次標準は、薬局方の1次標準に対する便利で対費用効果の高い代替品を医薬品研究室と製薬企業に提供します。

アプリケーション

Chlorhexidine digluconate may be used as a pharmaceutical reference standard for the determination of the analyte in eye drop formulations using capillary electrophoresis technique with contactless conductivity detection.[1]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的/生理学的作用

陽イオンの広い抗菌スペクトルを持つ抗生物質で、ビス(ビグアニド)系に含まれます。その作用のメカニズムは、細菌細胞外膜の不安定化が関与しています。カテ-テル挿入部位の創傷治癒、様々な歯科用途および外科手術の手洗いなど、主に局所的な防腐剤/殺菌剤として用いられます。

アナリシスノート

このような2次標準は、USP、EP(PhEur)、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC0252 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

ピクトグラム

CorrosionEnvironment

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1

保管分類コード

12 - Non Combustible Liquids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

PHR1294-1G:
PHR1294-1G-PW:


最新バージョンのいずれかを選択してください:

試験成績書(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 資料 section.

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Determination of chlorhexidine digluconate and polyhexamethylene biguanide in eye drops by capillary electrophoresis with contactless conductivity detection
Abad-Villar ME, et al.
Analytica Chimica Acta, 561(1-2), 133-137 (2006)
Discussion: does the use of biopatch devices at drain sites reduce perioperative infectious complications in patients undergoing immediate tissue expander breast reconstruction?
Deana Saleh Shenaq et al.
Plastic and reconstructive surgery, 135(1), 18e-19e (2014-12-30)
Jennifer B Wall et al.
Journal of critical care, 29(6), 1130-1130 (2014-07-19)
Although chlorhexidine gluconate (CHG) disks have been shown to help reduce the incidence of central line-associated blood stream infections, their use can result in local skin necrosis. The effects of CHG disks on patients with complex skin pathology have not
Staphylococcus aureus bacteraemia associated with peripherally inserted central catheters: the role of chlorhexidine gluconate-impregnated sponge dressings.
Michael J Loftus et al.
The Medical journal of Australia, 200(6), 317-318 (2014-04-08)
Data bits: take a swipe at surgical site infections.
Janet Bertoli et al.
Kentucky nurse, 62(2), 3-3 (2014-05-06)

質問

1–3/3 質問  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 回答
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 回答
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. Can I verify how much the total volume is per vial/ampule? I know the total concentration is 1G but since this is a solution I would like to confirm volume.

    1 回答
    1. This product has a specific gravity range of 1.06 – 1.07 which is reported on page 6 in the lot specific Certificate of Analysis. The 1 gram package size will have a volume of approximately 0.944 mL. Please see the link below to review a sample or lot specific Certificate:
      https://www.sigmaaldrich.com/product/sial/phr1294#product-documentation

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