PHR1138

アデノシン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 9-β-D-リボフラノシルアデニン, アデニン-9-β-D-リボフラノシド, アデニンリボシド
• 実験式（ヒル表記法）: C₁₀H₁₃N₅O₄
• CAS番号: 58-61-7
• 分子量: 267.24
• Beilstein: 93029
• EC Number: 200-389-9
• MDL番号: MFCD00005752
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823158
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to Ph. Eur. A0230200; traceable to USP 1012123
• APIファミリー: adenosine
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 234-236 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-8°C
• SMILES記法: Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• InChI: 1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI Key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
• 遺伝子情報: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)

詳細

詳細

Adenosine is a purine nucleoside and a building block of RNA and many other biomolecules such as adenosine triphosphate and nicotinamide adenine dinucleotide. In the extracellular space, ecto-5′-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine. Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

Adenosine may be used as a pharmaceutical reference standard for the quantification of the analyte in infusion solutions using high-performance liquid chromatography technique and capillary electrophoresis.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

アデノシン受容体に作用する内因性神経伝達物質です。心臓保護作用はA₁アデノシン受容体の活性化に関連するものと考えられます。アデノシンの抗血小板作用および抗炎症作用は、A₂アデノシン受容体を介して起こると思われます。対照的に、アデノシンは、喘息や慢性閉塞性肺疾患(COPD)の炎症誘発性メディエ-タとも考えられています。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAA7134 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable