Fibroblast growth factor 23 (FGF-23) is also called Phosphatonin and Tumor-derived hypophosphatemia-inducing factor. FGF-23 belongs to the heparin-binding growth factors family and has several important functions including: regulation of phosphate homeostasis, inhibition of renal tubular phosphate transport, upregulation of EGR1 expression, regulation of vitamin-D metabolism, and negative regulation of osteoblast differentiation and matrix mineralization. FGF-23 is expressed in osteogenic cells, adult trabecular bone, osteocytes and flattened bone-lining cells (inactive osteoblasts). Defects in FGF23 can lead to autosomal dominant hypophosphataemic rickets (ADHR) and hyperphosphatemic familial tumoral calcinosis (HFTC).
免疫原
Corresponding to human FGF23.
アプリケーション
Research Category 細胞シグナル伝達
Research Sub Category 発生シグナル伝達
Anti-FGF23 Antibody, clone 278-2 is a mouse monoclonal antibody & validated for use in western blotting.
Flow Cytometry Analysis: 2 µg from a representative lot detected FGF23 in Jurkat and human PMBC cells.
品質
Evaluated by Western Blotting in human salivary gland tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected FGF23 in 10 µg of human salivary gland tissue lysate.
ターゲットの説明
~25 kDa observed
物理的形状
Protein A purified
Format: Purified
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.
保管および安定性
Stable for 1 year at 2-8°C from date of receipt.
アナリシスノート
Control Human salivary gland tissue lysate
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
