MABC730

Anti-SCARB1 Antibody, clone 5B8.2

clone 5B8.2, 1 mg/mL, from mouse

• 別名: Scavenger receptor class B member 1, SRB1, CD36 and LIMPII analogous 1, CLA-1, CD36 antigen-like 1, Collagen type I receptor, thrombospondin receptor-like 1, SR-BI, CD36
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: mouse
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 5B8.2, monoclonal
• 交差性: human
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry: suitable; western blot: suitable
• アイソタイプ: IgMκ
• NCBIアクセッション番号: NP_005496
• UniProtアクセッション番号: Q8WTV0
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SCARB1(949)

詳細

詳細

Scavenger receptor class B member 1 (SCARB1), or CD36L1, is the membrane bound cell surface receptor for high density lipoprotein (HDL) as well as a number of related compounds such as phospholipids, cholesterol ester, and phosphatidylserine and apoptotic cells (via their expression of phosphatidylserine on their extracellular surfaces). SCARB1 is also the receptor for Hepatitis C virus glycoprotein E2 and it facilitates the attachment and entry of HCV. SCARB1 plays a critical role in cholesterol homeostasis and mediates cholesterol transfer to and from the HDL protein carriers, a process known as reverse cholesterol transport. It is highly expressed in tissues that require free cholesterol such as the liver and steroidogenic tissues (adrenals, testis, ovary). SCARB1 expression has also been associated with particular cancers including chronic myeloid leukemia (CML), breast cancer, bladder carcinoma, and prostate cancer.

免疫原

Epitope: Extracellular domain

KLH-conjugated linear peptide corresponding to the extracellular domain of human SCARB1.

アプリケーション

Research Category
アポトーシス及び癌

Research Sub Category
アポトーシス-追加

Detect SCARB1 using this Anti-SCARB1 Antibody, clone 5B8.2 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SCARB1 in human adrenal gland tissue.

品質

Evaluated by Western Blotting in human adrenal tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SCARB1 in 10 µg of human adrenal tissue lysate.

ターゲットの説明

~61 kDa observed. Uncharacterized band(s) may appear in some lysates.

物理的形状

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable