Reacts with HBcAg (epitope recognized - around amino acid positions 70-80, major C determinant).
SPECIES REACTIVITIES:
Cross-reacts with woodchuck hepatitis virus core antigen (WHcAg), but not with duck hepatitis B virus core antigen (DHcAg).
免疫原
Epitope: Core Antigen
Recombinant purified HBcAg from E.coli
アプリケーション
Research Category 感染症
Research Sub Category 感染症-ウイルス
Anti-Hepatitis B Virus Antibody, core antigen, clone C1-5, a.a. 74-89 is an antibody against Hepatitis B Virus for use in ELISA, IF, IP, WB, IC, IH.
ELISA, immunoblotting, immunoprecipitation, immunofluorescent and immunoperoxidase staining of infected liver tissues and transfected cultured cells. Optimal working dilutions: for immunoblotting - 1:1000; for immunofluorescence - 1:200. Optimal working dilutions must be determined by the end user.
物理的形状
Ascitic fluid. Liquid in DMEM, containing 0.1% sodium azide.
保管および安定性
Maintain at -20°C in undiluted aliquots for up to 12 months.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Hepatitis B virus is a major human pathogen, which forms enveloped virus particles. During viral maturation, membrane-bound hepatitis B surface proteins package hepatitis B core protein capsids. This process is intercepted by certain peptides with an "LLGRMKG" motif that binds
Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.
Holmes, K; Shepherd, DA; Ashcroft, AE; Whelan, M; Rowlands, DJ; Stonehouse, NJ
The Journal of Biological Chemistry null
A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly
Stray, Stephen J, et al
Proceedings of the National Academy of Sciences of the USA, 102, 8138-8143 (2005)
The structure of the variable regions of mouse monoclonal antibodies to hepatitis B virus core antigen.
Skrivelis, V, et al.
Scandinavian Journal of Immunology, 37, 637-643 (1993)
Differentiation of core gene products of the hepatitis B virus in infected liver tissue using monoclonal antibodies