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結合体
conjugate (Glucosaminoglycan)
品質水準
形状
powder
比活性
≥300 units/mg dry wt.
メーカー／製品名
Calbiochem®
保管条件
OK to freeze
色
white
輸送温度
ambient
保管温度
−20°C
関連するカテゴリー
詳細
300 units/mg minimum, 50,000 units/vial. Suitable for biochemistry grade.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
Specifications:Activity: 300NF U/mg min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
アプリケーション
Hyaluronidase has been used:
- to enzymatically remove extra-cellular matrix (ECM) to assess the lateral diffusion of the synaptic a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR)
- to study the effects of 4-methylumbelliferone (4MU)/ hyaluronidase (HLX)-mediated depletion of the CD44/hyaluronan complex on trastuzumab binding in JIMT1 breast cancer xenografts
- as a component of Hank′s balanced salt solution (HBSS) medium to digest fetal intestine tissue
生物化学的／生理学的作用
Hyaluronidase is an endoglycosidase that degrades hyaluronic acid (HA), a component of the extracellular matrix. It is used to enhance drug diffusion and reverse the effects of HA filler injections. Hyaluronidases dissolve the subcutaneous nodules and can correct excessive quantities of injected filler. It eliminates the cumulus-corona-oocyte complex formed during intracytoplasmic sperm injection. Hyaluronidase inhibits tissue damage after the extravasation of several substances. It is used for reducing edema treating vitreous hemorrhage.
単位の定義
One unit is based on the change in absorbency (turbidity) at 540 nm of an internal standard assayed concurrently with each lot. Internal standard replaces USP/NF reference no longer available.
物理的形状
Dialyzed, lyophilized powder, not less than300 units per mg (dry weight).
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Resp. Sens. 1
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
HX0514-1:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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Maurizio Cavallini et al.
Aesthetic surgery journal, 33(8), 1167-1174 (2013-11-08)
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive
Alexander D B Ross et al.
STAR protocols, 2(2), 100597-100597 (2021-06-26)
Here, we describe protocols for the preparation and dissociation of human fetal and pediatric intestinal tissue to a high-viability epithelial single-cell suspension. This epithelium-enriched single-cell suspension can then be used to generate single-cell RNA sequencing data as well as to
Sang Hak Lee et al.
eLife, 6 (2017-07-28)
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent
Patricia M R Pereira et al.
Molecular pharmaceutics, 17(1), 327-337 (2019-12-06)
Human epidermal growth factor receptor 2 (HER2) is a biomarker in breast cancer, and its overexpression is required to initiate therapies using HER2-targeted antibodies. Although trastuzumab is one of the most effective therapeutic antibodies in HER2-overexpressing breast cancer, a significant
資料
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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