440025

Luteolin

An antioxidant flavonoid and a free radical scavenger.

• 別名: Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
• 実験式（ヒル表記法）: C₁₅H₁₀O₆
• CAS番号: 491-70-3
• 分子量: 286.24
• MDL番号: MFCD00017309
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• 詳細: Merck USA index - 14, 5614
• アッセイ: ≥90% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: aqueous base: 1.4 mg/mL; DMSO: 7 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(cc(c2)O)O
• InChI: 1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
• InChI Key: IQPNAANSBPBGFQ-UHFFFAOYSA-N

詳細

詳細

An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G₂/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
rat liver cytosolic glutathione S-transferase activity

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

その他情報

Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable