215901

Carbonic Anhydrase IX/XII Inhibitor II, U-104

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

• 別名: Carbonic Anhydrase IX/XII Inhibitor II, U-104, CAIX Inhibitor II
• 実験式（ヒル表記法）: C₁₃H₁₂FN₃O₃S
• 分子量: 309.32
• MDL番号: MFCD00159265
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: Fc1ccc(cc1)NC(=O)Nc2ccc(cc2)[S](=O)(=O)N
• InChI Key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

詳細

詳細

A cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (K_i = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (K_i = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4^Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

その他情報

Lock, F.E., et al. 2012. Oncogenein press.
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable