212385-M

Carbachol

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.

• 別名: Carbachol, Carbamoylcholine Chloride
• 実験式（ヒル表記法）: C₆H₁₅ClN₂O₂
• CAS番号: 51-83-2
• 分子量: 182.65
• MDL番号: MFCD00012011
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (titration)
• 形状: solid (fine crystalline)
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: methanol: 100 mg/mL; water: 100 mg/mL; ethanol: 20 mg/mL
• 保管温度: 10-30°C
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
• InChI Key: AIXAANGOTKPUOY-UHFFFAOYSA-N

詳細

詳細

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca²⁺ and InsP₃ and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

生物化学的／生理学的作用

Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors

警告

Toxicity: Highly Toxic (H)

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

その他情報

Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 2 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable