211875

Captopril

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA4 hydrolase (IC₅₀ = 11 µM).

• 別名: Captopril, [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline, SQ-14225
• 実験式（ヒル表記法）: C₉H₁₅NO₃S
• CAS番号: 62571-86-2
• 分子量: 217.29
• MDL番号: MFCD00168073
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white to off-white
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• InChI Key: FAKRSMQSSFJEIM-RQJHMYQMSA-N

詳細

詳細

An antihypertensive agent that competitively inhibits angiotensin-converting enzyme (ACE; IC₅₀= 23-35 nM) and acts as a reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Inhibits angiogenesis and slows the growth of experimental tumors in rats. Reported to inhibit apoptosis in human lung epithelial cells (IC₅₀ = ~ 320 nM).

An antihypertensive agent. Reversible and competitive inhibitor of LTA₄ hydrolase (IC₅₀ = 11 µM). Also a competitive inhibitor of angiotensin-converting enzyme (ACE). Inhibits angiogenesis and slows the growth of experimental tumors in rats.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
ACE

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 23-35 nM against angiotensin-converting enzyme (ACE); 11 µM against LTA4 hydrolase; ~ 320 nM inhibiting apoptosis in human lung epithelial cells

警告

Toxicity: Carcinogenic / Teratogenic (D)

その他情報

Uhal, B.D., et al. 1998. Am. J. Physiol.275, L1013.
Volpert, O.V., et al. 1996. J. Clin. Invest.98, 671.
Voors, A.A., et al. 1995. J. Cardiovasc. Risk2, 413.
Orning, L., et al. 1991. J. Biol. Chem. 266, 16507.
Kostis, J. 1988. Am. Heart J. 116, 1591.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H341,H360F
• 注意書き: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Muta. 2 - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable