14-920-M

CLK1, active

• UNSPSCコード: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

特性

• 由来生物: human
• 品質水準: 100; 300
• 分子量: M_w 45 kDa
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• NCBIアクセッション番号: NM_004071
• UniProtアクセッション番号: P49759

詳細

詳細

CLK1 is a dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.

Product Source: N-terminal 6His-tagged, recombinant, human CLK1, amino acids 130-end expressed by baculovirus in Sf21 insect cells

生物化学的／生理学的作用

Target Sub-Family: CMGC

包装

Also available in 250μg size as catalog # 14-920M and in bulk as catalog # 14-920-K.

品質

Routinely evaluated by phosphorylation of peptide ERMRPRKRQGSVRRRV

物理的形状

Purified using immobilized metal affinity chromatography.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol

保管および安定性

6 months at -70°C

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable