Hämatoxylin-Monohydrat (C.I. 75290) for microscopy Certistain®, is a dye for the specific staining of DNA in the nuclei. It is used in cytology and histology. Nuclei are stained dark blue, dark violet to black. Hematoxylins are mixed with trivalent positively charged metal salts and build up the so-called hematoxylin lakes, used for the selective staining of nuclei (DNA). Certistain® is the quality group for seleceted high quality dyes that fulfill all quality requirements for IVD and CE registration. For more details, please see instructions for use (IFU). The IFU can be downloaded from this webpage.
アナリシスノート
Dye content (spectrophotometrically): ≥ 95 % Identity (UV/VIS-Spectrum): passes test Absorption maximum λ max (acetonitrile): 290 - 292 nm Spec. Absorptivity A 1%/1cm (λmax; 0.05 g/l; acetonitrile): 155 - 165 Haematein (spectrophotometrically): ≤ 0.1 % Water (according to Karl Fischer): 5 - 6 % Suitability for microscopy: passes test
法的情報
CERTISTAIN is a registered trademark of Merck KGaA, Darmstadt, Germany
The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. Evidence for WNT/β-catenin signaling-mediated immune evasion is found in a subset of cancers including