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薬剤管理
regulated under CDSA - not available from Sigma-Aldrich Canada
bp
128-132 °C/12 mmHg (lit.)
SMILES記法
CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-7H,8-10H2,1H3
InChI Key
PLRACCBDVIHHLZ-UHFFFAOYSA-N
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生物化学的／生理学的作用
ド-パミン作動性神経毒。
警告
Reportedly causes a severe and irreversible Parkinsonism condition in humans and monkeys. New Engl. J. Med. 1983, 309, 310. Science 1983, 219, 979. ibid. 1984, 224, 1083, 1451. ibid. 1984, 225, 529. J. Med. Chem. 1985, 28, 997.
シグナルワード
Danger
危険有害性情報
危険有害性の分類
Acute Tox. 3 Oral - STOT SE 1
保管分類コード
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
引火点(°F)
235.4 °F - closed cup
引火点(℃)
113 °C - closed cup
最新バージョンのいずれかを選択してください：
Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.
R E Heikkila et al.
Molecular and chemical neuropathology, 10(3), 171-183 (1989-06-01)
Cécile Moro et al.
BMC neuroscience, 14, 40-40 (2013-03-28)
We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Balb/c albino mice, a well-known model for Parkinson's disease. The present study explores
Sang-Bing Ong et al.
Thrombosis and haemostasis, 113(3), 513-521 (2014-09-26)
The mechanism through which the protein kinase Akt (also called PKB), protects the heart against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether Akt mediates its cardioprotective effect by modulating mitochondrial morphology. Transfection of HL-1 cardiac cells
Serge Przedborski et al.
Annals of the New York Academy of Sciences, 991, 189-198 (2003-07-09)
Experimental models of dopaminergic neurodegeneration play a critical role in our quest to elucidate the cause of Parkinson's disease (PD). Despite the recent development of "genetic models" that have followed upon the discovery of mutations causing rare forms of familial
Dominic J Hare et al.
Metallomics : integrated biometal science, 5(2), 91-109 (2013-01-17)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent toxin used to selectively destroy dopaminergic neurons in the substantia nigra and induce parkinsonism. MPTP is metabolised to the 1-methyl-4-phenylpyridinium ion (MPP(+)) in glia, after which it enters the neuron via the dopamine transporter and
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