916935

A1V2PF2-NHEt-PEG₁-NH₂

• 別名: (S)-1-((S)-2-((S)-2-((2-(2-Aminoethoxy)ethyl)amino)propanamido)-2-cyclohexylacetyl)-N-((S)-1-(ethylamino)-3-(4-fluorophenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide, AVP conjugate for IAP-mediated protein degrader development, SNIPER building block
• 実験式（ヒル表記法）: C₃₁H₄₉FN₆O₅
• 分子量: 604.76
• MDL番号: MFCD33021731
• UNSPSCコード: 41116105
• NACRES: NA.22

特性

• ligand: A1V2PF2
• 品質水準: 100
• フォーム: powder
• 反応適合性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 保管温度: 2-8°C
• SMILES記法: C[C@H](NCCOCCN)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(NCC)=O)CC2=CC=C(C=C2)F)=O)=O)C3CCCCC3)=O
• InChI: 1S/C31H49FN6O5/c1-3-34-29(40)25(20-22-11-13-24(32)14-12-22)36-30(41)26-10-7-17-38(26)31(42)27(23-8-5-4-6-9-23)37-28(39)21(2)35-16-19-43-18-15-33/h11-14,21,23,25-27,35H,3-10,15-20,33H2,1-2H3,(H,34,40)(H,36,41)(H,37,39)/t21-,25-,26-,27-/m0/s1
• InChI Key: WETVEUCXJVYEOI-ZYEMSUIVSA-N

詳細

アプリケーション

Protein degrader building block A1V2PF2-NHEt-PEG₁-NH₂ enables the synthesis of molecules for targeted protein degradation and SNIPER (specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers) technology. Developed in partnership with ComInnex, this conjugate contains an in silico-derived IAP-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with an acid on a target warhead. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and protein degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, including CRBN and VHL targeted, parallel synthesis can be used to more quickly generate SNIPER and PROTAC^® degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight.

Building blocks in this series:
916714 A1V2PF2-NHEt
917931 A1V2PF2-NHEt-C₆-NH₂
916684 A1V2PF2-NHEt-C₁₀-NH₂
916935 A1V2PF2-NHEt-PEG₁-NH₂
917192 A1V2PF2-NHEt-PEG₃-NH₂

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

その他情報

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable