748684

ホスゲン 溶液

15 wt. % in toluene

• 別名: Carbon oxychloride, Carbonyl chloride, Phosgen
• 化学式: COCl₂
• CAS番号: 75-44-5
• 分子量: 98.92
• Beilstein: 1098367
• MDL番号: MFCD00036119
• UNSPSCコード: 12352101
• PubChem Substance ID: 329765925
• NACRES: NA.22

特性

• 形状: liquid
• 品質水準: 200
• 濃度: 15 wt. % in toluene
• 密度: 0.924 g/mL at 25 °C
• 保管温度: 2-8°C
• SMILES記法: ClC(Cl)=O
• InChI: 1S/CCl2O/c2-1(3)4
• InChI Key: YGYAWVDWMABLBF-UHFFFAOYSA-N

詳細

詳細

Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.

アプリケーション

Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:

• γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
• 2-nitrobenzyl(4-vinylphenyl)carbamate

Phosgene solution may be used in the synthesis of:

• sulfonyl chlorides
• Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
• O-benzyl-L-serine carboxyanhydrides

包装

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

法的情報

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08,GHS05
• シグナルワード: Danger
• 危険有害性情報: H225,H304,H314,H330,H336,H361d,H373,H412
• 注意書き: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
• ターゲットの組織: Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 3
• 引火点(°F): 39.2 °F - closed cup
• 引火点(℃): 4 °C - closed cup