Although mechanisms of arsenic trioxide (As(2)O(3))-induced cell death have been studied extensively in hematologic cancers, those in solid cancers have yet to be clearly defined. In this study, we showed that the translocation of apoptosis-inducing factor (AIF) from mitochondria to
The Journal of pharmacology and experimental therapeutics, 332(1), 66-75 (2009-10-08)
Arsenic activates nuclear factor erythroid 2-related factor 2 (Nrf2) to induce phase II and antioxidative genes. Here we analyzed arsenic-Kelch-like ECH-associated protein 1 (Keap1) cysteine thiol interaction in Nrf2 activation. Arsenic-based Nrf2 activators, fluorescent biarsenical labeling reagent (FlAsH) and phenylarsine
The Science of the total environment, 557-558, 712-721 (2016-04-04)
The study aimed to evaluate the efficiency of dithiocarbamate functionalized silica coated magnetite nanoparticles (NPs) for Hg decontamination of saltwater either contaminated with Hg alone or with As and Cd. For this, the residual levels of Hg in seawater were
World journal of gastroenterology, 13(48), 6498-6505 (2007-12-29)
To investigate the effect of arsenic trioxide (As2O3) on expression of vascular endothelial growth factor receptor-1 (VEGFR-1, Flt-1) and VEGFR-2 (KDR) in human gastric tumor cells and proliferation of vascular endothelial cells. The solid tumor model was formed in nude
As a first of its kind, we developed a highly sensitive colorimetric nanoprobe for phytic acid (PA) and Fe(III) ion detection based on 4-mercaptophenol (4MP) and thioglycolic acid (TGA)-functionalized gold nanoparticles {AuNPs@(4MP-TGA)}. AuNPs were easily derivatized by 4MP and TGA