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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

別名:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Species:
Human GABBR2 (9568), Mouse Gabbr2 (242425), Rat Gabbr2 (83633), domestic guinea pig Gabbr2 (100170764), naked mole-rat Gabbr2 (101719923), Horse GABBR2 (100063963), sheep GABBR2 (101103544), Domestic Rabbit GABBR2 (100346845), domestic cat GABBR2 (101093058), cow GABBR2 (517040) ...詳細
UniProtKB ID:
O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9
遺伝子ID:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2

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Small Molecule - Agonist

製品番号
詳細
Species
PHR1682
(±)-バクロフェン, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
1048200
(±)-バクロフェン, United States Pharmacopeia (USP) Reference Standard,
Species
human
B0200000
(±)-バクロフェン, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP028
(±)-バクロフェン, British Pharmacopoeia (BP) Reference Standard,
Species
human
B5399
(±)-バクロフェン, ≥98% (HPLC), solid,
Species
human, rat

Small Molecule - Allosteric Modulator

製品番号
詳細
Species
C0987
CGP-13501, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

製品番号
詳細
Species
A6566
2-ヒドロキシサクロフェン, ≥98% (TLC), solid,
Species
human
P118
ファクロフェン, solid,
Species
human
B5399
(±)-バクロフェン, ≥98% (HPLC), solid,
Species
human, rat
S166
サクロフェン, solid,
Species
mouse, human, rat
A2129
γ-アミノ酪酸, ≥99%,
Species
human, rat

Antibodies

製品番号
詳細
交差性
アプリケーション
SAB6012076
Anti GABBR2 Antibody, clone 23GB5500, Rabbit Monoclonal, clone 23GB5500, recombinant rabbit monoclonal, expressed in HEK293 cells,
交差性
human, rat
アプリケーション
western blot
AB2255
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
交差性
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
アプリケーション
immunohistochemistry
western blot
G9920
Anti-GABAB Receptor 2 ウサギ宿主抗体, affinity isolated antibody, lyophilized powder,
交差性
rat
アプリケーション
western blot
SAB5200418
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
交差性
human, mouse, rat
アプリケーション
immunocytochemistry
immunohistochemistry
western blot
HPA013820
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry

Small Molecule - Inhibitor

製品番号
詳細
Species
N142
NO-711 塩酸塩, ≥98% (HPLC),
Species
human
V8261
(±)-ビガバトリン, ,
Species
human

esiRNA

製品番号
詳細
Species
EHU002331
MISSION® esiRNA, targeting human GABBR2,
Species
human