コンテンツへスキップ
Merck

EGFR

epidermal growth factor receptor

別名:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
遺伝子ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor

Custom & Knockdown Gene Products

ELISA

製品番号
詳細
Species
Human EGFR / ErbB1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Species
human
Phospho-EGFR (pSer1070) ELISA Kit, for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates,
Species
human
Cell-Based ELISA for detecting phospho-EGFR, in cultured cell lines, 96 assays,
Species
human
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates,
Species
human

Small Molecule - Antagonist

製品番号
詳細
Species
チルホスチンAG 1478, ≥98%,
Species
human, mouse
SU 5416, ≥98% (HPLC),
Species
human, mouse
ゲニステイン, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat
ゲニステイン, from Glycine max (soybean), ~98% (HPLC),
Species
mouse, human, rat

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-EGFRvIII Antibody, clone DH8.3, clone DH8.3, from mouse,
交差性
human
アプリケーション
ELISA
flow cytometry

immunohistochemistry

immunoprecipitation (IP)

western blot
抗EGF受容体抗体、マウスモノクローナル マウス宿主抗体, clone 225, purified from hybridoma cell culture,
交差性
human
アプリケーション
immunoprecipitation (IP)
抗EGFR抗体、中和、クローンLA1, clone LA1, Upstate®, from mouse,
交差性
human
アプリケーション
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

neutralization

western blot
モノクロナール抗上皮成長因子受容体 マウス宿主抗体, clone F4, ascites fluid,
交差性
human
アプリケーション
ELISA
immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-EGFR Antibody, clone LA22, clone LA22, Upstate®, from mouse,
交差性
human
アプリケーション
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
ゲフィチニブ, ≥98% (HPLC),
Species
human
エルロチニブ塩酸塩, ,
Species
human
ゲフィチニブ, European Pharmacopoeia (EP) Reference Standard,
Species
human
Tyrphostin 1, ≥98%,
Species
human
システム適合性用ゲフィチニブ, European Pharmacopoeia (EP) Reference Standard,
Species
human

Proteins

製品番号
詳細
Species
上皮増殖因子レセプター ヒト, lyophilized powder, ≥15,000 units/mg protein (Bradford),
Species
human
EGFR Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human
EGF-レセプター ヒト, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Species
human
上皮増殖因子レセプター ヒト, buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry),
Species
human
EGFR (T790M L858R) Active human, recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE),
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human EGFR,
Species
human
MISSION® esiRNA, targeting mouse Egfr,
Species
mouse