RAB0166

Phospho-EGFR (pTyr¹⁰⁶⁸) and pan-EGFR ELISA Kit

for detection of human phospho-egfr (pTyr¹⁰⁶⁸) and pan-egfr in cell and tissue lysates

• UNSPSCコード: 41116158
• NACRES: NA.32

特性

• 化学種の反応性: human
• 包装: kit of 96 wells (12 strips x 8 wells)
• テクニック: ELISA: suitable; capture ELISA: suitable
• 入力: sample type: human cell lysate; sample type: human tissue lysate
• 検出方法: colorimetric
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... EGFR(1965)

詳細

詳細

The Phospho-EGFR (pTyr¹⁰⁶⁸) ELISA (Enzyme-Linked Immunosorbent Assay) kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in cell lysates.

免疫原

EGFR (pTyr¹⁰⁶⁸) synthetic phosphopeptide, Recombinant Human EGFR

アプリケーション

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

生物化学的／生理学的作用

EGFR (epidermal growth factor receptor) functions as a receptor for EGF-family of proteins, which are peptide growth factors. This receptor-ligand system is also involved in the pathogenesis and progression of various types of carcinomas. In cancer, EGFR pathways promotes cellular proliferation, angiogenesis, metastasis and apoptosis. The microRNA miR-218-5p interacts with and controls EGFR, and in non-small cell lung cancer (NSCLC), the levels of EGFR are inversely related to miR-218-5p. miR-218-5p inhibits proliferation and migration of lung cancer cells by binding with EGFR, and thus, has potential in future NSCLC therapies. Phospho-EGFR activates phospho-Akt pathway in invasive bladder cancer (BC) and it can be considered as a promising therapeutic target for cancer.

その他情報

Phosphorylated and pan protien can both be measured , in one experimnet.

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Warning
• 危険有害性情報: H290
• 注意書き: P234 - P390
• 危険有害性の分類: Met. Corr. 1
• 保管分類コード: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable