V900931
Trichostatin A
Vetec™, reagent grade, from Streptomyces sp., ≥98%
Sinonimo/i:
Trichostatin A, TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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About This Item
Formula empirica (notazione di Hill):
C17H22N2O3
Numero CAS:
Peso molecolare:
302.37
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
Prezzi e disponibilità al momento non sono disponibili
Prodotti consigliati
Origine biologica
Streptomyces sp.
Grado
reagent grade
Nome Commerciale
Vetec™
Saggio
≥98%
Temperatura di conservazione
−20°C
Stringa SMILE
C[C@H](\C=C(C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
RTKIYFITIVXBLE-QEQCGCAPSA-N
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Azioni biochim/fisiol
Trichostatin A (TSA) inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. Trichostatin A serves as an epigenetic modifier.
Trichostatin A inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression.
Note legali
Vetec is a trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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