1096724

Carmustine

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: 1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU
• Formula empirica (notazione di Hill): C₅H₉Cl₂N₃O₂
• Numero CAS: 154-93-8
• Peso molecolare: 214.05
• Numero MDL: MFCD00057706
• Codice UNSPSC: 41116107
• ID PubChem: 329749246
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: carmustine
• Stato: (Oily liquid to amorphous solid)
• Produttore/marchio commerciale: USP
• Punto di fusione: 30 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Temperatura di conservazione: −20°C
• Stringa SMILE: ClCCNC(=O)N(CCCl)N=O
• InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11); DLGOEMSEDOSKAD-UHFFFAOYSA-N
• Informazioni sul gene: human ... GSR(2936)

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

• Enhancing glioblastoma treatment: Overexpression of Let-7a-3p in U87MG glioblastoma cells enhances chemosensitivity to Carmustine, promoting autophagy and suppressing cell survival, suggesting its role in improving outcomes in glioblastoma multiforme treatment using antineoplastic alkylating compounds (Bahojb Mahdavi et al., 2024).


• Pharmacogenomic profiling in renal cancer: Characterization of mitoribosomal small subunit genes in renal cell carcinoma reveals significant implications for Carmustine′s pharmacogenomic interaction, enhancing understanding of its mechanism in cancer therapy and providing a basis for personalized treatment approaches (Wei et al., 2024).

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H350,H360
• Consigli di prudenza: P201 - P280 - P301 + P330 + P331 + P310 - P308 + P313
• Classi di pericolo: Acute Tox. 2 Oral - Carc. 1B - Repr. 1B
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable