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Merck
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Documenti

L5918

Sigma-Aldrich

Lomustine

≥98%

Sinonimo/i:

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

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About This Item

Formula empirica (notazione di Hill):
C9H16ClN3O2
Numero CAS:
13010-47-4
Peso molecolare:
233.70
Numero CE:
235-859-2
Numero MDL:
MFCD00012392
Codice UNSPSC:
12352100
ID PubChem:
329817632
NACRES:
NA.25

Saggio

≥98%

Temperatura di conservazione

−20°C

Stringa SMILE

ClCCN(N=O)C(=O)NC1CCCCC1

InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
GQYIWUVLTXOXAJ-UHFFFAOYSA-N

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Azioni biochim/fisiol

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301,H350

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 3 Oral - Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Bendamustine hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

B5437

Bendamustine hydrochloride hydrate

Temozolomide VETRANAL®, analytical standard

Supelco

76899

Temozolomide

Vincristine sulfate salt 95.0-105.0% (HPLC), powder or crystals

Sigma-Aldrich

V8879

Vincristine sulfate salt

Gefitinib ≥98% (HPLC)

Sigma-Aldrich

SML1657

Gefitinib

SAHA ≥98% (HPLC)

Sigma-Aldrich

SML0061

SAHA

Cisplatin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1624

Cisplatin

Carsten Friedrich et al.
European journal of cancer (Oxford, England : 1990), 49(4), 893-903 (2012-11-28)
Medulloblastoma in adulthood is rare. Knowledge is limited, and the efficacy and toxicity of chemotherapy--especially in nonmetastatic disease--is still elusive. Seventy adults aged ≥21 years (median age: 28.5 years) with nonmetastatic medulloblastoma were followed as observational patients within the prospective
Enrico Franceschi et al.
Neuro-oncology, 14(12), 1503-1510 (2012-10-24)
The treatment of patients with recurrent glioblastoma remains a major oncologic problem, with median survival after progression of 7-9 months. To determine the maximum tolerated dose and dose-limiting toxicity (DLT), the combination of dasatinib and cyclonexyl-chloroethyl-nitrosourea (CCNU) was investigated in
Joann L Ater et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30(21), 2641-2647 (2012-06-06)
PURPOSE Surgery is curative therapy for pediatric low-grade gliomas (LGGs) in areas of the brain amenable to complete resection. However, LGGs located in areas where complete resection is not possible can threaten both function and life. The purpose of this
C F Saba et al.
Veterinary and comparative oncology, 10(4), 283-291 (2012-01-13)
Treatment of feline vaccine-associated sarcoma (VAS) is challenging, in part due to the high likelihood of tumour recurrence despite aggressive local therapy. Lomustine is potentially an attractive agent to add to the current treatment armamentarium. In this de-escalating phase I/II
Daisuke Hasegawa et al.
The Journal of veterinary medical science, 74(11), 1517-1521 (2012-07-13)
A 9 year-old, neutered, male French Bulldog showing cluster seizures was diagnosed with a glioma in the right piriform cortex by MRI. Hypofractionated radiation therapy (RT) was performed using a linear accelerator. Although the lesion had involuted significantly at 2
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