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47864

Supelco

Acido nicotinico

analytical standard

Sinonimo/i:

Acido 3-picolinico, Acido piridin-3-carbossilico, Fattore di prevenzione della pellagra, Niacina, Vitamina B3

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1000 MG
50,00 €

50,00 €


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Cambia visualizzazione
1000 MG
50,00 €

About This Item

Formula empirica (notazione di Hill):
C6H5NO2
Numero CAS:
Peso molecolare:
123.11
Beilstein:
109591
Numero CE:
Numero MDL:
Codice UNSPSC:
12164500
ID PubChem:

50,00 €


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Grado

analytical standard

CdA

current certificate can be downloaded

Caratteristiche

standard type water soluble vitamin

Confezionamento

ampule of 1000 mg

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

236-239 °C (lit.)

Densità

1.473 g/cm3 at 25 °C

applicazioni

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
PVNIIMVLHYAWGP-UHFFFAOYSA-N

Informazioni sul gene

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Descrizione generale

Nicotinic acid acts as an antilipolytic drug in adipose tissue, and is commonly used for hyperlipoproteinaemia and pellagra.[1]
Nicotinic acid is a water soluble[2], vitamin belonging to B complex group of vitamins[3], which can be used as a broad spectrum lipid lowering drug.[4] Its mode of action basically involves the inhibition of the hormone-sensitive triglyceride lipase and thereby, decreasing the lipolysis in adipose tissue.[3][4]

Applicazioni

Nicotinic acid may be used as an analytical reference standard for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.[1]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

379.4 °F - closed cup

Punto d’infiammabilità (°C)

193 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

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I clienti hanno visto anche

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Acido nicotinico European Pharmacopoeia (EP) Reference Standard

Y0001995

Acido nicotinico

Molecular identification of nicotinic acid receptor
Soga T, et al.
Biochemical and Biophysical Research Communications, 303, 364-369 (2003)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Tunaru S, et al.
Nature Medicine, 9, 352-352 (2003)
Nicotinic acid: the broad?spectrum lipid drug. A 50th anniversary review
Carlson.A.L
J. Int. Med., 258, 94-114 (2005)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
John R Guyton et al.
Journal of the American College of Cardiology, 62(17), 1580-1584 (2013-08-07)
This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial. During a

Domande

1–3 di 3 domande  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  3. questo standard è certificato iso17034 o iso 17025?

    1 risposta
    1. Analytical standards are not ISO 17025 or 17034 certified. This level of certification is for a certified reference material such as product PHR1276.

      https://www.sigmaaldrich.com/product/sial/phr1276

      Utile?

Recensioni

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