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W4262

Sigma-Aldrich

1400W dihydrochloride

>98%, solid

Sinonimo/i:

N-([3-(aminomethyl)phenyl]methyl)ethanimidamide

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10 MG
214,00 €

214,00 €

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214,00 €

About This Item

Formula empirica (notazione di Hill):
C10H15N3 · 2 HCl
Numero CAS:
214358-33-5
Peso molecolare:
250.17
Numero MDL:
MFCD03428622
Codice UNSPSC:
12352200
ID PubChem:
24278778
NACRES:
NA.77

214,00 €

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Saggio

>98%

Stato

solid

Condizioni di stoccaggio

desiccated

Ideatore

GlaxoSmithKline

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1

InChI

1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
WDJHSQZCZGPGAA-UHFFFAOYSA-N

Informazioni sul gene

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Applicazioni

1400W dihydrochloride has been used:
  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat[1]
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction[2]
  • to study its efficacy on renal ischemia/ reperfusion injury in rats[3]
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation[4]

Azioni biochim/fisiol

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Caratteristiche e vantaggi

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000132679
0000132679
0000131222
0000107881
0000060237

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Nω-Nitro-L-arginine ≥98% (TLC)

Sigma-Aldrich

N5501

Nω-Nitro-L-arginine

L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis

Sigma-Aldrich

C1625

L-Canavanine

NG-Nitro-L-arginine Methyl Ester, Hydrochloride Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Sigma-Aldrich

483125-M

NG-Nitro-L-arginine Methyl Ester, Hydrochloride

Diphenyleneiodonium chloride ≥98%

Sigma-Aldrich

D2926

Diphenyleneiodonium chloride

Mifepristone ≥98%

Sigma-Aldrich

M8046

Mifepristone

Coenzyme Q10 ≥98% (HPLC)

Sigma-Aldrich

C9538

Coenzyme Q10

Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
1400 W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia
Shi Q, et al.
Behavioural Brain Research, 319(8), 188-199 (2017)
Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
Sandy Santos-Pereira et al.
PloS one, 14(12), e0226837-e0226837 (2019-12-20)
Leishmaniasis encompass a group of infectious parasitic diseases occurring in 97 endemic countries where over one billion people live in areas at risk of infection. It is in the World Health Organization list of neglected diseases and it is considered
E P Garvey et al.
The Journal of biological chemistry, 272(8), 4959-4963 (1997-02-21)
N-(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of inhibition by 1400W showed saturation kinetics with a maximal rate constant of 0.028 s-1 and a binding constant of 2.0 microM.
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