V1255

D-Valine

suitable for cell culture, BioReagent

• Sinonimo/i: (R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid
• Formula condensata: (CH₃)₂CHCH(NH₂)CO₂H
• Numero CAS: 640-68-6
• Peso molecolare: 117.15
• Beilstein: 1721135
• Numero CE: 211-368-9
• Numero MDL: MFCD00064219
• Codice UNSPSC: 12352209
• ID PubChem: 24900713
• NACRES: NA.75

Proprietà

• Origine biologica: synthetic (organic)
• Nome Commerciale: BioReagent
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Punto di fusione: >295 °C (subl.) (lit.)
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: CC(C)[C@@H](N)C(O)=O
• InChI: 1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1; KZSNJWFQEVHDMF-SCSAIBSYSA-N

Descrizione

Descrizione generale

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Applicazioni

D-Valine has been used as a supplement in:

• Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture[1]
• endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture[2]
• DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture[3]

Azioni biochim/fisiol

D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.[4]

D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)